Results 21 to 30 of about 41,054 (268)

Dendritic cells steering antigen and leukocyte traffic in lymph nodes

FEBS Letters, EarlyView.
Dendritic cells are key players in the activation of T cells and their commitment to effector function. In this In a Nutshell Review, we will discuss how dendritic cells guide the trafficking of antigen and leukocytes in the lymph node, thus influencing T‐cell activation processes. Dendritic cells (DCs) play a central role in initiating and shaping the
Enrico Dotta, Agnieszka Katarzyna Maciola, Tania Baccega, Giulia Pasqual   +3 more
wiley   +1 more source

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

FEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali, Gloria Giacomello, Michela Vuono, Silvia Gregori   +3 more
wiley   +1 more source

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

A 3D View of Orion. I. Barnard's Loop

The Astrophysical Journal, 2023
Barnard’s Loop is a famous arc of H α emission located in the Orion star-forming region. Here, we provide evidence of a possible formation mechanism for Barnard’s Loop and compare our results with recent work suggesting a major feedback event occurred in
Michael M. Foley, Alyssa Goodman, Catherine Zucker, John C. Forbes, Ralf Konietzka, Cameren Swiggum, João Alves, John Bally, Juan D. Soler, Josefa E. Großschedl, Shmuel Bialy, Michael Y. Grudić, Reimar Leike, Torsten Enßlin   +13 more
doaj   +1 more source

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

Signatures of Mass Segregation from Competitive Accretion and Monolithic Collapse

The Astrophysical Journal
The two main competing theories proposed to explain the formation of massive (>10 M _⊙ ) stars—competitive accretion and monolithic core collapse—make different observable predictions for the environment of the massive stars during, and immediately after,
Richard J. Parker, Emily J. Pinson, Hayley L. Alcock, James E. Dale   +3 more
doaj   +1 more source

Star Formation and Molecular Gas Diagnostics with Mid- and Far-infrared Emission

The Astrophysical Journal, 2023
With the start of JWST observations, mid-infrared (MIR) emission features from polycyclic aromatic hydrocarbons (PAHs), H _2 rotational lines, fine structure lines from ions, and dust continuum will be widely available tracers of gas and star formation ...
C. M. Whitcomb, K. Sandstrom, A. Leroy, J.-D. T. Smith   +3 more
doaj   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Direct Observational Evidence of Multi-epoch Massive Star Formation in G24.47+0.49

The Astrophysical Journal Letters
Using new continuum and molecular line data from the Atacama Large Millimeter/submillimeter Array Three-millimeter Observations of Massive Star-forming Regions (ATOMS) survey and archival Very Large Array, 4.86 GHz data, we present direct observational ...
Anindya Saha, Anandmayee Tej, Hong-Li Liu, Tie Liu, Guido Garay, Paul F. Goldsmith, Chang Won Lee, Jinhua He, Mika Juvela, Leonardo Bronfman, Tapas Baug, Enrique Vázquez-Semadeni, Patricio Sanhueza, Shanghuo Li, James O. Chibueze, N. K. Bhadari, Lokesh K. Dewangan, Swagat Ranjan Das, Feng-Wei Xu, Namitha Issac, Jihye Hwang, L. Viktor Tóth   +21 more
doaj   +1 more source

The ALMA Survey of 70 μm Dark High-mass Clumps in Early Stages (ASHES). IX. Physical Properties and Spatial Distribution of Cores in IRDCs

The Astrophysical Journal, 2023
The initial conditions found in infrared dark clouds (IRDCs) provide insights on how high-mass stars and stellar clusters form. We have conducted high-angular resolution and high-sensitivity observations toward thirty-nine massive IRDC clumps, which have
Kaho Morii, Patricio Sanhueza, Fumitaka Nakamura, Qizhou Zhang, Giovanni Sabatini, Henrik Beuther, Xing Lu, Shanghuo Li, Guido Garay, James M. Jackson, Fernando A. Olguin, Daniel Tafoya, Ken’ichi Tatematsu, Natsuko Izumi, Takeshi Sakai, Andrea Silva   +15 more
doaj   +1 more source