Results 31 to 40 of about 41,054 (268)

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

The intracellular domain of TLR2 is capable of high‐affinity Zn binding: possible outcomes for the receptor activation

FEBS Letters, EarlyView.
Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa, Cong Lin, Irina A. Talyzina, Marina V. Goncharuk, Eduard V. Bocharov, Alexander S. Arseniev, Xiaohui Wang, Sergey A. Goncharuk, Konstantin S. Mineev   +8 more
wiley   +1 more source

Alignment Parameters: Quantifying Dense Core Alignment in Star-forming Regions

The Astrophysical Journal
Recent high-resolution observations at millimeter (mm) and submillimeter wavelengths reveal a diverse spatial distribution for subparsec-scale dense cores within star-forming regions, ranging from clustered to aligned arrangements.
Wei-An Chen, Ya-Wen Tang, S. D. Clarke, Patricio Sanhueza   +3 more
doaj   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

The ALMA-QUARKS Survey: Fibers’ Role in Star Formation Unveiled in an Intermediate-mass Protocluster Region of the Vela D Cloud

The Astrophysical Journal
In this paper, we present a detailed analysis of the IRS 17 filament within the intermediate-mass protocluster IRAS 08448-4343 (of ∼10 ^3 L _⊙ ), using ALMA data from the ATOMS 3 mm and QUARKS 1.3 mm surveys.
Dongting Yang, Hong-Li Liu, Tie Liu, Anandmayee Tej, Xunchuan Liu, Jinhua He, Guido Garay, Amelia Stutz, Lei Zhu, Sheng-Li Qin, Fengwei Xu, Pak-Shing Li, Mika Juvela, Pablo García, Paul F. Goldsmith, Siju Zhang, Xindi Tang, Patricio Sanhueza, Shanghuo Li, Chang Won Lee, Swagat Ranjan Das, Wenyu Jiao, Xiaofeng Mai, Prasanta Gorai, Yichen Zhang, Zhiyuan Ren, L. Viktor Tóth, Jihye Hwang, Leonardo Bronfman, Ken’ichi Tatematsu, Lokesh Dewangan, James O. Chibueze, Suinan Zhang, Gang Wu, Jinjin Xie   +34 more
doaj   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Multiple Generation Star Formation in Cepheus Flare

The Astronomical Journal
We present an analysis of the young stellar moving group ASCC 127 using Gaia DR3 data, significantly expanding its membership to 3971 stars—double the number identified in previous studies.
Fan Wang, Min Fang, Xiaoting Fu, Yang Su, Xuepeng Chen, Shiyu Zhang, Penghui Liu, Xiao-Long Wang, Haijun Tian, Wenyuan Cui, Zhongmu Li   +10 more
doaj   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Global and Local Infall in the ASHES Sample (GLASHES). I. Pilot Study in G337.541

The Astrophysical Journal
Recent high-angular-resolution observations indicate the need for core growth to form high-mass stars. To understand the gas dynamics at the core scale in the very early evolutionary stages before being severely affected by feedback, we have conducted ...
Kaho Morii, Patricio Sanhueza, Timea Csengeri, Fumitaka Nakamura, Sylvain Bontemps, Guido Garay, Qizhou Zhang   +6 more
doaj   +1 more source

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source