Results 31 to 40 of about 294,326 (210)
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
A New Mathematical Model for Evolutionary Games on Finite Networks of Players [PDF]
, 2013 A new mathematical model for evolutionary games on graphs is proposed to extend the classical replicator equation to finite populations of players organized on a network with generic topology.
Madeo, Dario, Mocenni, Chiara
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Game Theoretic Formation of a Centrality Based Network
, 2012 We model the formation of networks as a game where players aspire to maximize their own centrality by increasing the number of other players to which they are path-wise connected, while simultaneously incurring a cost for each added adjacent edge.
Griffin, Christopher, Tatko, Ryan
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Kleene Algebras and Semimodules for Energy Problems [PDF]
, 2013 With the purpose of unifying a number of approaches to energy problems found in the literature, we introduce generalized energy automata. These are finite automata whose edges are labeled with energy functions that define how energy levels evolve during ...
A. Degorre +22 more
core +5 more sources
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
“Searching for order at all levels”. Antonio Lima-de-Faria (July 4, 1921 – December 27, 2023)
CaryologiaProfessor Antonio Lima-de-Faria was our friend and, in a sense, a teacher. Despite our different fields of study, this master of scientific thought has deeply influenced both of us. Dr.
Stefano Serafini, Tatyana S. Turova
doaj +1 more source
Optimal Budget Allocation in Social Networks: Quality or Seeding
, 2014 In this paper, we study a strategic model of marketing and product consumption in social networks. We consider two competing firms in a market providing two substitutable products with preset qualities. Agents choose their consumptions following a myopic
Ajorlou, Amir +2 more
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Network architecture, salience and coordination [PDF]
, 2008 This paper reports the results of an experimental investigation of monotone games with imperfect information. Players are located at the nodes of a network and observe the actions of other players only if they are connected by the network. These games
Choi, S. +3 more
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