Results 81 to 90 of about 635,631 (297)
Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli +10 morewiley +1 more sourceCirculating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong +6 morewiley +1 more sourceMulti-functional star tracker — future perspectives
Acta Polytechnica, 2011 This paper focuses on the idea of a multi-functional wide-field star tracker (WFST) and provides a description of the current state-of-the-art in this field. The idea comes from a proposal handed in to ESA at the beginning of 2011.J. Roháč, M. Řeřábek, R. Hudecdoaj Alignment of the CMS silicon strip tracker during stand-alone commissioning [PDF]
, 2009 This is the Pre-print version of the Article. The official published version of the paper can be accessed from the link below - Copyright @ 2009 IOPThe results of the CMS tracker alignment analysis are presented using the data from cosmic tracks, optical Brom J-, Broccolo, B., Wickens J, Drouhin F, Luzhetskiy N., Mattiazzo S., Sarkar S, Yang, Z., Petagna P., Jeng G. Y., Serban, AT, Bainbridge R., De Weirdt, S., Kalavase, P, Pooth, O, Mammini, P, Abbaneo, D., Delattre, M., Borrello L, Bernardini J., Covarelli, R., Adler V., Steininger H, Maes J., Paccagnella, A, Miner, D, Pozzobon, N, Profeti A, Lowette, S, Petragnani G., Zoeller MH, Ligabue, F., Rubinstein, N, Wilke L., Haroutunian, R, Steinbrueck G, Hashemi, M., Gerber, CE, Contardo, D., Trocme, B., Kloukinas, K, Chierici R., Paoletti S, Huhtinen M, Servoli, L., Chiochia, V., Romero A., Pesaresi M., Raupach F, White D, Macchiolo, A, Zerev E, Checcucci B, de Wolf E. A., Ernenwein J-, Rouby, X., Gotra, Y., Tosi, M., Mariani F., White, D, Widl E., Ciulli V., Moulik T, Coughlan J., Foa, L, Albergo S., Bianucci S., Slav A., Fahrer M, Tran, N. V., Eßer, Hans, Wickens J., Gillissen C., Mills C, Kreyer, S, Bhat, PC, Schirra F., Gateau M, Siegrist P., Villella, I, Dell'Orso, R, Burke S, Staszak, D, Raffaelli, F, Heyninck, J, Saizu, MA, DEWULF JP, Pernicka M., Scarlini E, Gregoire G., Nigro M., ERNENWEIN JP, Donckt, MV, Chen J, Johnson, M, Dragicevic, M, Lamb J, Luukka, PR, Zhukov V, Butz, E., Ernenwein, JP, Noeding C., Karpinski, W, Tonelli G., Adam W, Schleper, P, Simonis H-, Pierschel, G., Johnson M, Onnela, A, Rizzi D, Delmeire, E., Bhat, P. C., Tuve C, Hobson, P.R., Kalavase P, Rizzi A, Waltenberger, W., Wlochal, M., Regenfus C, Bonnevaux, A., Giraud N, Bacchetta N, Bruno G., Taghavi, S, Harris, P, Balestri, G., Goerlach, U., Roberfroid V, Krammer, M, Everaerts, P., JENG GY, Bracci F., Beaumont, W., Mason D., Zatserklyaniy, A, Bonnevaux A, Vander Velde, C., Fiori, F., Migliore, E., Marage P, et al, Liamsuwan T., Tonelli G, Hoffmann, K.-H., Schmidt, Alexander, Mozer M, Cariola P, Sigaud C, MY, Salvatore, Van Lancker L., Tomalin I., Hansel, S, Jensen, H., Delaere C, Vanlaer, P, Fahrer M., Spiga, D., Lenzi, P., Sanguinetti, G, Ledermann, B, Ligabue, F, Karpinski, Waclaw, Lounis A., HOFFMANN KH, Tropea, P., Tolaini, S, Sguazzoni, G, Saizu M. A., Michal, S, Chabanat E., Goorens R, Burkett K., Guardone, N, Zorba, O., Bacchetta, N, Raffaelli F, Anghel I, Hammad G, Pesaresi M, Crook A., Nahn, S, Gill, K, Affolder, K, Delmeire E, Steck P., Affolder, T, Vlimant, J. R., Cole J, Ronga, F., Thomas M, Giammanco A., Parrini, G, Gross, L, Allen A., Simonis, H. J., Wingham, M, Giraud, N, Vanlaer P, Mozer M., D'Alfonso M., Basti, A, Keutgen T, Schmidt, A., Berretta L., Cattai A, Hamdorf R, Chiorboli, M, Kortesmaa, J, Dumitrache, F, Anttila, E, Barge D., De Palma M, My S., Simonis, H.-J., Berretta L, Kyre, S., Preda M., Simms L, Abbaneo D., Fulcher, J., Pantano, D., Pernicka M, Swain, S., De Filippis, N., Silvestris L, D'Alfonso M, Edera, L.M., Lariccia, P, Bosi, F, Garberson, J., Dewulf, J.-P., Venturi, A, Biasini M, Cariola P., Jaditz, S, Bean A, De Mattia M., Hobson, P. R., de Lentdecker G., Zaccarelli, L, Flucke, G, Giorgi M, Rebassoo, F, Chabert E, Eppard, M., Zito, G, Karimaki V, Raupach, Frank Arthur, Baulieu, G., Schwering G, Miao T, Heyninck J, Alagoz, E, Tsirou, A., Boudoul, G., Buchmuller O, Selvaggi, G., Cerati G, Manna N., De La Cruz-Burelo, E., Liu, H., Meschini, M, Piccut C, Mannelli, M., Lomtadze, T, Tuominen, E, Landi, G., Hanson, G., Hrubec J, Demaria N, Schwering, G, Buhmann, P, Sanhueza, S, Giordano D., Bianucci S, Bock, E, Hall, G., Saizu, M.A., Sigaud C., Devroede, O, Kostesmaa, J, Radicci, V., Abbaneo D, Clerbaux B, Zorba, O, Berst, JD, Magini N, Ambroglini F, Olzem J., Bock, Eric, Delmeire, E, Frosali S, Spiegel L, Vander Donckt, M., Eppard M., Breuker H., Grabit R, Oberegger M., Ronzhin, A., Karimaki, V., Ribnik J, Dobur, D., Amsler C, Galanti, M., Hinchey C., Goitom, I, Bhat, P.C., Mc Guinness, C, Dell'Orso, R., Leonardo, N., De Filippis N., Karpinski W, Cazzola, U., Lariccia P, Petrucciani G., Broccolo B., Azzi P., Pozzobon, N., Kostesmaa, J., Sprenger D., Beaumont W., Sutera, C., Vanzetto S., Butz E., Kaminski, J, Mirabito, L, Poettgens M., Tsang, K. V., Clerbaux B., Magazz, G., Gritsan A. V., Swain S., Kottelat L. J., Bernardini, J., Delaere, C., Villella, I., Benotto, F, Gelin G, Sigaud, C., Robmann, P, Lungu, G. A., Martinelli G, Khomenkov V., CALZOLARI, FEDERICO, Hashemi M, Berst, J.-D., J. C. Fontaine, Null, Sharp P., Ulmer, KA, Steininger, H, Anagnostou G, Pooth, Oliver, Elgammal, S., Moccia, S., Siegrist, P., Adler V, Blaes, R., Edera, LM, Tsirou A., Schael, S, Azzi P, Brianzi M, Mueller T.h., Kukulies C, Roberfroid, V, Fulcher J., MUFFAT JOLY J, Skup, E., Segneri, G, Hrubec J., Manolescu F., Preda, M., Scarlini E., Skup, E, Benucci L., Genta, C., Creanza, D., Moccia S., Postema H, De Palma M., Mc Guinness C, Ledermann B, Tessaro M., Devroede, O., Bean, A., Mason, D., Guardone N, Raupach, F., Ulmer, K.A., Delaere C., Covarelli R, Agram J. L., Ribnik, J, Feld L., Dietch, J., Kyre S, Friedl, M., Santocchia A, Baringer, P, Karimaki V., Brauer R, Bazterra VE, Thomas, M, Bagliesi, G, Covarelli, R, Ostapchuk, A., Sprenger, D., Hinchey C, Tenchini R., Lamb, J., Nigro, M., Avanzini C, Chabanat E, Bagliesi, G., Van Mechelen P, Didierjean F, J. P. Dewulf, Null, Jensen, H, Lamb, J, Hashemi M., Biasini, M, Postema, H, Giudice, N., Gritsan AV, Stuart D., Tropea P., Lowette S, Harkonen J., Steiner S, Della Negra, R., Mannelli M, Gay A, Mueller S, Vanzetto, S., Mueller T, Maletta F, Cattai, A., Korjenevski, S, Giorgi, M., Anagnostou G., Tuominen E, Hahn, K. A., Bergauer T, Klein, K., Campagnari, C., De Mattia, M., Stoye M., Linn A, Magazzu G., Olivetto, C., Grabit, R., Paoletti, S, Demaria, N, Olivetto C., Pein, U, Civinini C, Bean A., Selvaggi G, Syed, A., Drouhin F., Sparti V, Tropea P, Friedl M., Calzolari F., Agram, J.-L., Albergo, S., Beissel, F, Serban AT, Hartmann, F, SCHILLING FP, Benucci L, Tessaro M, Ricci D, Van Hove, P., Goitom, I., Piotrzkowski K., Bluem P., Yang Z., Giordano D, Fulcher J, Ribnik, J., SELVAGGI, Giovanna, Farano R., Tuominiemi J, Steiner, S, Mannelli, M, Boudoul, G, Martin, C, Gerber CE, Ahmed I., Teodorescu, L, Staszak, D., Kaminsky A, Zhukov, V, Fo, L., Demina, R, Spalding, WJ, Akhtar I, Lemaitre, Vincent, Elgammal S., Foà, L., Della Negra R., Boccali, T, Cucoanes, A. S., Profeti, A., Yang Z, Buhmann, P., Hosselet J., Giorgi, MA, Rommerskirchen T, Rommerskirchen T., Gay A., Ernenwein, J.-P., Zaccarelli, L., Regenfus, C., Miao, T, Hermanns T, Hartmann, F., Furgeri, A, Selvaggi G., Messineo, A, Heydhausen D, Masetti L, Brauer, R., Klanner, R, Tricomi, A, Giassi, A., Schmid, S, Orbaker, D., Butt, S, Pasztor, G, Heyninck, J., Ricci D., Wastiels C, Tuve, C, Gateau, M., Spiga, D, Esser H., Marchioro A., Robinson R, Schilling F-, Macchiolo A, Raupach, F, Klein K., Beissel F, Sguazzoni, G., Serban, T., Borgia MA, Hermanns, T., Linden T., Hahn, KA, Reznikov S, Fiore, L, Beißel, Franz, Bagliesi G, Muller, S., Shah, Y., Borrello L., Teodorescu, L., Dewulf J. P., Zito G, Liu H., Nigro M, Caponeri, B., Kaminski, J., Kreyer S, Harris, P., Lemaitre V, Delattre M, Callahan, D, Kartashov D., Teyssier D, Harkonen J, Stahl A, Marcantonini, M, Caponeri B., Vlimant, JR, Kraan A, Perchalla L., Olzem J, Pantano D, Hosselet, J., Mersi S., Bisello, D, Sala, G, Kortesmaa J, Frühwirth, R., Troska J, Manna N, Giubilato, P, Hooper, R., Anagnostou, G., Contardo D., Schilling F. P., Goorens R., Incandela, H, Giammanco, A., Ulmer KA, Zerev E., Sparti V., Bhat P. C., Incandela, J, Van Mulders, P, Wittmer B., Mantovani G., Ostapchuk A, Reid, ID, Daubie E., Dierlamm A, Sentenac, D., Ulmer, K. A., Profeti, A, Reid, I., Dutta S, Spiga D., Hosselet J, Garberson, J, White, D., Trocme, B, Flucke, G., Hermanns T., Tomalin I, Maazouzi, C., Ronzhin A, Giudice N., Sharp, P., Luzhetskiy, N., Robinson, R, Palmonari F., Bilei, G.M., Ulmer, A., Ceccanti M., Cripps N., Liu H, Demaria, N., Santocchia A., Babucci, E, Vanlaer, P., Perries S., Checcucci B., Grabit, R, Sharp P, Stoner J., Mueller, S., Flugge G., Jeng, GY, Marcantonini M, Keutgen, Thomas, Focardi, R. DAlessandro. E., Edera L. M., Linden, T, Maggi G., Militaru, O, Michal, S., Guillot, G, Mariani, F., BONNET JL, Pal, I, Pandoulas D, Dorigo, T, Bonnet, Jean-Luc, Genta C, Gutsche, O, Masetti L., Petragnani G, Nikolic, M., Beissel, F., Zöller, Marc Henning, Tuominiemi J., Linn, A., Richman, J, Castaldi R, Michotte, D, Bouhali, O, Noto F., Marchioro, A, Kcira D., Abbas, M., Breuker, H., Garberson J, Ahmed I, Dupasquier, T, Maazouzi C., Gregoire G, Keutgen, Th., Creanza, D, Dierlamm A., Ronga F., Tkaczyk S., Nguyen, H., Genta C., Parrini G, Bocci, A, Civinini C., Cerati, G., Karimaki, V, Wagner, S. R., Lungu GA, Schmid S, Stark R., Khalatian, S., Furgeri A, Brianzi, M, Nahn, S., Heier, S, Cerati, GB, Focardi, E., Fahrer, M., Gennai, S, Maes, J., Saizu, M. A., Costa S., Raymond D. M., Moggi, A, Steininger H., Tolaini, S., Cucoanes, S., Abbas, M, Paccagnella, A., Devroede O, J. P. Ernenwein, Null, Costa, M., Spagnolo, P, Cattai, A, Engstrom P, Giolo-Nicollerat, A.-S., Pein, U., Guardone, N., Hauk, J, Zoeller, M. H., Costa S, Rolandi G., Schmid, S., Costa M, Karaevski S, Kottelat, L.J., Tricomi, A., Costa M., Martinelli, G., Pioppi M., Johnson, M., Dorigo, T., Piccut C., Marage P., Baringer P., Spiegel, L, Albert, E, Costa, S., Ciulli, V., Shah Y., Focardi, RDE, Servoli, L, Amsler C., Mills, C, Jaditz S, Fruehwirth R., Wagner S. R., Crook A, Zhukov, Valery, Noto, F., Everaerts, P, Lampen T., Hoffmann K. H., Stringer, R, de Boer, W., Manolescu F, Frey, M., Stark, R., Hanson G., Skup E, Raffaelli, F., Postolache V., Soldani, A, Kaussen, G, Spalding, J., Cazzola, U, Charaf, O, Castello, R, Gelin, G., Loreti M., Speer, T, Wittmer, B., Schilling, F.-P., De Mattia M, Avanzini, C, Chiochia, V, Gross L, Martinelli G., Goerlach, U, Maes J, Giolo-Nicollerat, AS, Cardaci, M., Chen J., Tavernier, S, Silvestris, L, Babucci, E., Campagnari, C, Tomalin, I., de Wolf EA, Fano L, Nikolic, M, Lumb N, Dutta, S., Ostapchuk A., Sentenac D., Frey, M, Steinbrück, G., Albert, E., Pantano D., Bhat PC, Benedetti, D, Kraan, A, Giolo-Nicollerat A-, Stahl, A, Ferorelli R, Teyssier, D., Kyre S., Farano R, Wagner, S.R., Juillot, P, Van Lancker, L., Burke S., Hall G, Flucke G., Chabanat, E., Ligabue F, Wlochal, M, Linari S, Martin, C., Ranieri, R, De Weirdt S, Pandoulas D., Czellar S., Spalding WJ, Nguyen H., Ljuslin C., Bagby L., Cerri, C, Piotrzkowski, Krzysztof, Roberfroid, V., Preda M, Pozzobon N, Spalding, W. J., de Langhe E., Cihangir, S, Sarkar, S., Incandela, J., Rizzi, D., Borgia, M.A, Kcira D, Mc Guinnessr, C., Strub R., Widl, E., Candelori, A., Cardaci M., Palmonari F, Mozer, Matthias Ulrich, Richman, J., De Callatay, B., De Robertis G., D'Hondt J, Alagoz E., Engstrom P., Serban A. T., Adler, V, Chabert E., FONTAINE JC, BERST JD, Gill K, Rubinstein N, Bock E, Regenfus, C, Delattre, M, Kloukinas, K., Allen, A., Simonis H. J., Guardone N., Incandela, H., Gennai S, Juillot P, Nguyen, D., Florins, B, Azzurri, P., Stoye, M., Huhtinen M., Tosi M., Bainbridge R, Fiori, F, Buchmuller O., Zatserklyaniy, A., Lenzi, P, Maletta, F., Kukulies, C, Troska J., Leonardo N, Tonelli, G., Verdini, P.G., Speer, T., Creanza D, Potenza R., Pierschel G, Galanti M., Krammer M, Foa L, Butt, S., Eppard M, D'Hondt J., Migliore E., Ronga F, Civinini, C., Hoffmann, KH, Bonnevaux A., Massa, M, Quertermont, L, Focardi, R. D.a.l.e.s.s.a.n.d.r.o. E., Wastiels, C, Petragnani, G., Satpathy A., Bosi, F., Hartmann F, Adam, W., Shabalina E., Liamsuwan T, Dirkes G., Pioppi, M., Lampen T, Rolandi G, Baulieu G., Migliore E, Schmidt, A, Goorens, R., Mantovani G, Poettgens M, Raymond DM, Wickens, J., Pal, I., HANSEL S, De Boer W., Chierici, R, Hammad, G., Amsler, C., Gay, APR, Landi G., Orbaker, D, Chabert, E., Kostesmaa J, Magini, N, Ageron, M, Schael, S., Estre, N, Chiorboli, M., Uhl D., Ambroglini F., Bainbridge, R, Hammad, GH, Ernenwein J. P., Ricci, D., Boccali T, Zerev, E., Didierjean, F, Linari, S, Haroutunian R, Maenaa, T., Kuronen A, Jahn D., Kaussen G, Linn A., Heydhausen, D, Church I., Bruno, Giacomo, BISELLO, DARIO, Satpathy, A., Simms, L, Tempesta P., Azzurri P., Tkaczyk, S., Soldani, A., Pooth, O., Hamdorf, R, Noeding, C, Yumiceva, F, Sguazzoni G, Syed, A, Rochet J, Giassi, A, Butz E, Cecchi, R., Honma A., Babucci E, Sung, K., Lemaitre, V, Dobur, D, Pierschel G., Velde, C. Vander, Garberson, Jeffrey Ford, Gateau M., Vasey F., Perries S, Moulik T. +999 morecore +1 more sourceSomatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan +6 morewiley +1 more sourceExtracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer
Molecular Oncology, EarlyView.Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon +9 morewiley +1 more sourceRecent highlights from STAR
EPJ Web of Conferences, 2018 The Solenoidal Tracker at RHIC (STAR) experiment takes advantage of its excellent tracking and particle identification capabilities at mid-rapidity to explore the properties of strongly interacting QCD matter created in heavy-ion collisions at RHIC.Zha Wangmeidoaj +1 more sourceAutonomous Star Tracker Algorithms
, 1998 Proposal, in response to an ESA R.f.P., to design algorithms for autonomous star tracker operations.The proposal also included the development of a star tracker breadboard to test the algorithms ...Thuesen, Gøsta, Kilsgaard, Søren, Betto, Maurizio, Jørgensen, John Leif, Madsen, Peter Buch, Riis, Troels +5 morecore
