Results 51 to 60 of about 4,861,001 (122)

Isolation and characterization of a spontaneously immortalized bovine retinal pigmented epithelial cell line

BMC Cell Biology, 2009
Background The Retinal Pigmented Epithelium (RPE) is juxtaposed with the photoreceptor outer segments of the eye. The proximity of the photoreceptor cells is a prerequisite for their survival, as they depend on the RPE to remove the outer segments and ...
Griffiths T Daniel, Liggett Thomas E, Gaillard Elizabeth R   +2 more
doaj   +1 more source

Progressive binocular visual alterations associated with increasing myopic anisometropia in spectacle‐corrected children

Optometry and Vision Science, Volume 103, Issue 8, August 2026.
ABSTRACT Purpose To characterize the severity‐dependent pattern of accommodative and binocular visual alterations in spectacle‐corrected children with myopic anisometropia, normal best‐corrected visual acuity (BCVA), and no clinically significant binocular vision‐related symptoms.
Ningxin Dou, Xiaodan Dong, Jiayan Li, Yunfan Li, Jiaqi Chen, Guoming Zhang, Yanling Zhang   +6 more
wiley   +1 more source

Low Vision Rehabilitation in Patients with Hereditary Retinal Dystrophy

Türk Oftalmoloji Dergisi, 2015
Objectives: To examine the methods of low vision rehabilitation in patients with hereditary retinal dystrophy. Materials and Methods: This study was conducted in Ankara University Faculty of Medicine, Ophthalmology Department of Low Vision ...
İkbal Seza Petriçli, Aysun İdil Merdoğan, Zuhal Özen Tunay, Özdemir Özdemir   +3 more
doaj   +1 more source

Mesopic microperimetry in Stargardt disease: Application and reliability

Acta Ophthalmologica, Volume 104, Issue 5, Page e544-e554, August 2026.
Abstract Purpose Mesopic microperimetry (mMP) is a promising functional endpoint in clinical trials for Stargardt disease type 1 (STGD1). This study evaluated the test–retest variability of mMP and influencing factors, which is essential for ensuring reliability in future STGD1 trials.
Sybren H. Kootstra, Jeroen A. A. H. Pas, Patty P. A. Dhooge, Steffen Schmitz‐Valckenberg, Maurizio Battaglia Parodi, Philipp Herrmann, Frank G. Holz, Andrew J. Lotery, Katarina Stingl, Thomas H. Wheeler‐Schilling, Camiel J. F. Boon, Carel B. Hoyng, Soraprazan Consortium   +12 more
wiley   +1 more source

Identification and functional validation of a novel disease‐causing variant in the noncoding region of NYX

Acta Ophthalmologica, Volume 104, Issue 5, Page e555-e564, August 2026.
Abstract Purpose Inherited retinal diseases (IRDs) are a clinically and genetically heterogeneous group of disorders, with ~30% of cases remaining genetically unsolved. Complete congenital stationary night blindness (cCSNB) is a subtype of IRD, usually associated with reduced visual acuity, nystagmus and high myopia.
Filip Spanic, Christelle Michiels, Julien Navarro, Aline Antonio, Christel Condroyer, Camille Andrieu, Billy Gipsy, Sylvie Berthémy‐Pellet, Mathilde Gallice, Isabelle Audo, Christina Zeitz   +10 more
wiley   +1 more source

Stem Cell Therapy for Retinal Degeneration: The Evidence to Date

Biologics: Targets & Therapy, 2021
Amit Sharma, Bithiah Grace Jaganathan Stem Cells and Cancer Biology Research Group, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam, 781039, IndiaCorrespondence: Bithiah Grace JaganathanStem Cells ...
Sharma A, Jaganathan BG
doaj  

ABCA4‐Associated Retinal Degeneration in 8 Families From the Three Provinces of Northeast China: Identification and Characterization of Potentially Novel Variants

Molecular Genetics &Genomic Medicine, Volume 14, Issue 7, July 2026.
This study reports the documented case of ABCA4‐associated early‐onset severe retinal dystrophy in China, broadens the mutational spectrum of ABCA4 in this population, and highlights distinct genotype–phenotype correlations that may inform clinical management and genetic counseling.
Nian Li, Linlin Su, Yue Ren, Ye Liu, Jiayuan Ge, Henan Sun, Zhuoshi Wang   +6 more
wiley   +1 more source

An easyguide to rare diseases in Ireland and consensus for action for government, the general public, media and political parties [PDF]

, 2020
The aims of this guide are to: • Explain what a rare disease is and how it is defined in health policy • Provide insights into living with a rare disease • Identify priorities patient advocacy groups would urge the Irish Government to include in the
IPPOSI, Health Research Charities Ireland, /, Rare Disease Ireland   +2 more
core  

Stem cell therapy as treatment for Stargardt disease

Therapeutic Advances in Ophthalmology
Stargardt disease or Juvenile Macular Degeneration is a rare genetic disorder caused by a mutation in the ABCA4 gene that results in degeneration of the macula and loss of central vision.
Erica Marks, Adith Anugu, Joseph Bisiani, Srinivas Pentyala   +3 more
doaj   +1 more source

Unveiling the Power of Deuterium in Drug Discovery: A Comprehensive Overview

MedComm, Volume 7, Issue 6, June 2026.
The role of deuterium replacement in drug discovery, its progress, opportunities, and challenges. ABSTRACT Deuterium, the heavy isotope of hydrogen, has unfolded as a cornerstone in modern drug discovery due to its potential to influence metabolic stability and pharmacokinetic behavior.
Mukta Lele, Ajit Manchare, Swapnali Parit, Amol D. Gholap, Krishna Jadhav, Navnath Hatvate, Keshav Raj Paudel, Satish Rojekar   +7 more
wiley   +1 more source