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Fundus Flavimaculatus and Stargardt's Disease
American Journal of Ophthalmology, 1976Of 42 patients studied who had fundus flavimaculatus and Stargardt's disease, most had reduced visual acuity due to an atrophic macular lesion. Family histories were consistent with autosomal-recessive inheritance. In some young patients, the yellow-white flecks developed with time, while in some older patients the flecks faded, pari passau with ...
O B, Hadden, J D, Gass
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Novel therapeutics for Stargardt disease
Graefe's Archive for Clinical and Experimental Ophthalmology, 2017Stargardt disease, an inherited macular dystrophy caused by mutations in the ABCA4 gene encoding a retinal transporter protein, is the most prevalent form of macular degeneration in children. Patients with Stargardt disease develop severe vision loss within their first or second decades of life, which progresses to irreversible decreased visual acuity ...
Louise J, Lu, Ji, Liu, Ron A, Adelman
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1993
Stargardt’s disease is an autosomal recessive condition in which the retina displays characteristic yellow flecks often associated with macular degeneration. The degeneration appears similar to that seen with fundus flavimaculatus. It is debated, however, whether these two entities are distinct or represent two points on the spectrum of a single ...
Juan Orellana, Alan H. Friedman
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Stargardt’s disease is an autosomal recessive condition in which the retina displays characteristic yellow flecks often associated with macular degeneration. The degeneration appears similar to that seen with fundus flavimaculatus. It is debated, however, whether these two entities are distinct or represent two points on the spectrum of a single ...
Juan Orellana, Alan H. Friedman
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Color vision in Stargardt's disease
International Ophthalmology, 1992The color vision of nine patients aged from 13 to 52 years with Stargardt's disease was studied with the following tests: Standard Pseudoisochromatic Plates part 2 (SSP2), Farnsworth-Munsell 100 hue test (FM100), Nagel (red-green) anomaloscope and Besançon (blue) anomalometer.
M, Mäntyjärvi, K, Tuppurainen
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Stargardt's Disease and Fundus Flavimaculatus
Archives of Ophthalmology, 1979A study of 67 patients with a diagnosis of Stargardt's disease (juvenile macular degeneration) or fundus flavimaculatus showed that, apart from the ophthalmoscopic appearance, there is no clear distinction between these two disorders. The disease is an autosomal recessive macular degeneration that is bilateral and symmetrical in appearance, with ...
K G, Noble, R E, Carr
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Dual AAV Vectors for Stargardt Disease
2017Stargardt disease (STGD1), due to mutations in the large ABCA4 gene, is the most common inherited macular degeneration in humans. Attempts at developing gene therapy approaches for treatment of STGD1 are currently ongoing. Among all the vectors available for gene therapy of inherited retinal diseases, those based on adeno-associated viruses (AAV) are ...
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Non-viral Gene Therapy for Stargardt Disease with ECO/pRHO-ABCA4 Self-Assembled Nanoparticles
Molecular Therapy, 2020Da Sun, Rebecca M Schur, Avery E Sears
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Prognostication in Stargardt Disease Using Fundus Autofluorescence: Improving Patient Care
Ophthalmology, 2023Michel Michaelides +2 more
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