Results 81 to 90 of about 10,317 (215)

Cone Spacing Correlates With Retinal Thickness and Microperimetry in Patients With Inherited Retinal Degenerations. [PDF]

, 2019
PurposeTo determine whether high-resolution retinal imaging measures of macular structure correlate with visual function over 36 months in retinal degeneration (RD) patients and normal subjects.MethodsTwenty-six eyes of 16 RD patients and 16 eyes of 8 ...
Baldwin, Angela, De la Huerta, Irina, Duncan, Jacque L, Foote, Katharina G, Gustafson, Kevin, Porco, Travis C, Rinella, Nicholas, Roorda, Austin, Zayit-Soudry, Shiri   +8 more
core   +1 more source

Scavenging of retinoid cation radicals by urate, trolox, and α-, β-, γ-, and δ-tocopherols [PDF]

, 2019
Retinoids are present in human tissues exposed to light and under increased risk of oxidative stress, such as the retina and skin. Retinoid cation radicals can be formed as a result of the interaction between retinoids and other radicals or ...
Edge, R, Land, EJ, Navaratnam, S, Rozanowska, M, Sarna, T, Truscott, TG   +5 more
core   +3 more sources

Long‐term predictive outcomes of stem cell therapy for degenerative retinal diseases

Eye &ENT Research, Volume 2, Issue 4, Page 247-263, December 2025.
Abstract Background Stem cell transplantation is a promising therapy for degenerative retinal diseases, including age‐related macular degeneration (AMD), retinitis pigmentosa (RP), and Stargardt's disease (STGD). This study quantitatively evaluates long‐term outcomes of different stem cell treatments.
Hai‐Long He, Xuan‐Yu Chen, Ming‐Xia Du, Yi‐Hui Li, Yi‐Han Wang, Zi‐Bing Jin   +5 more
wiley   +1 more source

Stargadt’s disease in two Nigerian siblings

International Medical Case Reports Journal, 2013
Tunji S Oluleye, Akinsola Sunday Aina, Tarela Frederick Sarimiye, Segun Isaac Olaniyan Retinal and Vitreous Unit, University College Hospital, Ibadan, Nigeria Abstract: Stargardt’s disease is an inherited macular dystrophy that is transmitted in an
Oluleye TS, Aina AS, Sarimiye TF, Olaniyan SI   +3 more
doaj  

The relevance of genetic counseling in various forms of hereditary retinal dystrophies

Офтальмохирургия, 2016
Purpose. Retrospective genetic counseling analysis of patients with hereditary retinal diseases.Material and methods. The study is based on an analysis of genetic counseling and molecular genetic studies of DNA samples of 82 patients: Stargardt disease ...
B. E. Malyugin, S. A. Borzenok, O. V. Khlebnikova, M. F. Shurygina, P. M. Arbukhanova, A. N. Loginova, P. L. Volodin, S. A. Zubareva   +7 more
doaj   +1 more source

A pathogenic in-frame deletion-insertion variant in BEST1 phenocopies Stargardt disease

JCI Insight, 2022
Here, we describe affected members of a 2-generation family with a Stargardt disease–like phenotype caused by a 2–base pair deletion insertion, c.1014_1015delGAinsCT;p.(Trp338_Asn339delinsCysTyr), in BEST1.
Masha Kolesnikova, Jin Kyun Oh, Jiali Wang, Winston Lee, Jana Zernant, Pei-Yin Su, Angela H. Kim, Laura A. Jenny, Tingting Yang, Rando Allikmets, Stephen H. Tsang   +10 more
doaj   +1 more source

Fluorescence Lifetime Imaging Techniques—A Review on Principles, Applications and Clinical Relevance

Journal of Biophotonics, Volume 18, Issue 12, December 2025.
This article gives an overview of the most frequently used fluorescence‐lifetime imaging (FLIM) techniques, their capabilities and typical applications in biology and clinical studies. ABSTRACT This article gives an overview of the most frequently used fluorescence‐lifetime imaging (FLIM) techniques, their capabilities, and typical applications ...
V. I. Shcheslavskiy, M. V. Shirmanova, K. S. Yashin, A. C. Rück, M. C. Skala, W. Becker   +5 more
wiley   +1 more source

Molecular diagnosis of putative Stargardt disease probands by exome sequencing

BMC Medical Genetics, 2012
Background The commonest genetic form of juvenile or early adult onset macular degeneration is Stargardt Disease (STGD) caused by recessive mutations in the gene ABCA4. However, high phenotypic and allelic heterogeneity and a small but non-trivial amount
Strom Samuel P, Gao Yong-Qing, Martinez Ariadna, Ortube Carolina, Chen Zugen, Nelson Stanley F, Nusinowitz Steven, Farber Deborah B, Gorin Michael B   +8 more
doaj   +1 more source

Blue light regenerates functional visual pigments in mammals through a retinyl-phospholipid intermediate. [PDF]

, 2017
The light absorbing chromophore in opsin visual pigments is the protonated Schiff base of 11-cis-retinaldehyde (11cRAL). Absorption of a photon isomerizes 11cRAL to all-trans-retinaldehyde (atRAL), briefly activating the pigment before it dissociates ...
Fain, Gordon L, Hakobyan, Hayk, Ingram, Norianne T, Kaylor, Joanna J, Travis, Gabriel H, Tsan, Avian, Xu, Tongzhou   +6 more
core   +1 more source

Functional and Transcriptional Disruption of Hepatic ABC Transporters by Environmentally Relevant Short‐Chain Per‐ and Polyfluoroalkyl Substances (PFAS)

Journal of Biochemical and Molecular Toxicology, Volume 39, Issue 12, December 2025.
Low‐dose short‐chain PFAS exposures enhance hepatic ABC transporter activity and expression, revealing that environmentally relevant concentrations can reprogram xenobiotic transport pathways and potentially influence drug metabolism, bile acid handling, and lipid homeostasis, highlighting a molecular link between chronic PFAS exposure and altered ...
Gracen E. Collier, Ramon Lavado
wiley   +1 more source