Results 41 to 50 of about 5,740 (219)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Abundances in J-Type Carbon Stars [PDF]

International Astronomical Union Colloquium, 1988
It has been found by Utsumi(1985a,b) that in J-type carbon stars of C4-5 and WZ Cas(C9,2J Li), abundances of s-process elements with respect to Fe are nearly normal, while in normal carbon stars of C5-8, heavy metals are overabundant by factors of 10-100, and rare-earth elements are overabundant by a factor of about 10.In the MK system, most J-type ...
openaire   +1 more source

Elemental Abundances in Symbiotic Stars [PDF]

Symposium - International Astronomical Union, 1993
Symbiotic objects are related to planetary nebulae in that they represent late stages of stellar evolution. They are interacting binary systems where a hot companion star ionizes the stellar wind of a red giant. This configuration offers the unique possibility for deriving elemental abundances for cool giants from a nebular spectrum with the diagnostic
H. M. Schmid, H. Nussbaumer
openaire   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

On the Hydrogen Abundance in Wolf-Rayet Stars [PDF]

Symposium - International Astronomical Union, 1984
With a semiempirical NLTE-model in spherical geometry we investigate the hydrogen abundance in Wolf-Rayet stars. We find that the flux contribution of the H-Balmer to the He-Pickering lines lies between the usually applied approximate formulae for the optically thin and optically thick case. This result can be understood with our finding that there are
openaire   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Abundances and Kinematics of Field Stars. II. Kinematics and Abundance Relationships [PDF]

The Astronomical Journal, 2002
As an investigation of the origin of ``$α$-poor'' halo stars, we analyze kinematic and abundance data for 73 intermediate metallicity stars ($-1 >$ [Fe/H] $\geq -2$) selected from Paper I of this series. We find evidence for a connection between the kinematics and the enhancement of certain element-to-iron ([X/Fe]) ratios in these stars ...
openaire   +2 more sources