Results 151 to 160 of about 2,858,112 (243)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

MMP9 shapes cell mechanics to enable collective invasion in cancer. [PDF]

NPJ Syst Biol Appl
Asadullah, Dutta S, Saha SK, Karmakar A, Sharma N, Vijayakumar S, Sen S.   +6 more
europepmc   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

History of individual presolar SiC grains revealed by stellar winds. [PDF]

Nat Commun
Bajo KI, Izumi T, Otsuki Y, Amari S, Yurimoto H.   +4 more
europepmc   +1 more source

Mass Loss and Evolution of Stars and Star Clusters: a Personal Historical Perspective [PDF]

, 2007
H. J. G. L. M. Lamers
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Hysteretic self-oscillatory acoustic radiation with tunable orbital angular momentum. [PDF]

Sci Adv
Zhang L, Zou HY, Ge Y, Liu W, Sun HX, Chen F, Chen Q, Pan Y, Tong M, Hu Y, Han N, Wu B, Wu J, Yang Q, Yuan SQ, Chen H, Yang Y, Zhang S.   +17 more
europepmc   +1 more source

The Eclipsing Binary V1061 Cygni: Confronting Stellar Evolution Models for Active and Inactive Solar‐Type Stars [PDF]

, 2006
Guillermo Torres, Claud H. Sandberg Lacy, Laurence A. Marschall, Holly A. Sheets, J. Mader   +4 more
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Photometric light curve analysis of three overcontact binary systems: ATO J255.8159+16.8821, CRTS J034336.4+264312, and NSVS 2669503. [PDF]

Sci Rep
Shokry A, Darwish MS, El-Sadek MA, Hamed GM, Zead I, Takey A.   +5 more
europepmc   +1 more source