Results 181 to 190 of about 2,858,112 (243)

Precision analysis of NGC 2158 with Gaia DR3. [PDF]

Sci Rep
Ahmed NM, Tadross AL.
europepmc   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Exploring the extremes: The cosmic laboratory. [PDF]

Innovation (Camb)
Huang Y, He S, Ge L, Li Z, Mao Y, Liu J.
europepmc   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

MINISTAR to STARLITE: Evolution of a Miniaturized Prototype for Testing Attitude Sensors. [PDF]

Sensors (Basel)
Nardino V, Baccani C, Ceccherini M, Cecchi M, Focardi F, Franci E, Guzzi D, Manna F, Milli V, Pini J, Salvadori L, Raimondi V.   +11 more
europepmc   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

GLObal Solar Wind Structure (GLOWS). [PDF]

Space Sci Rev
Bzowski M, Wawrzaszek R, Strumik M, Baran J, Barciński T, Ber K, Bujwan W, Daukszo M, Jasiński K, Juchnikowski G, Kazmierczak P, Kowalska-Leszczyńska I, Kowalski T, Kubiak M, Ma̧dry J, Mirońska A, Mostowy K, Orleański P, Porowski C, Półtorak J, Rajkowski T, Rothkaehl J, Rudnicki T, Shmyk A, Sikorski A, Turek M, Winkler M, Wojciechowska K, Zawistowski T, Fahr HJ, Nass U, Osica P, Wielgos K, Gottwald A, Kaser H, Krzyzagorski M, Antoniak M, Drobik M, Gajoch G, Martyniak T, Żogała R, Bartnik A, Fiedorowicz H, Fok T, Majszyk M, Wachulak P, Wardzińska M, Wȩgrzyński Ł, Kosturek R, Urdiales C, Tapley M, Pope S, Reisenfeld DB, Gkioulidou M, Schwadron NA, Christian ER, McComas DJ.   +56 more
europepmc   +1 more source

Supernova-driven evolution of the first stars and galaxies

, 2018
Jeremy S. Ritter
openalex   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Employing deep-learning techniques for the conservative-to-primitive recovery in binary neutron star simulations. [PDF]

Eur Phys J A Hadron Nucl
Mudimadugula R, Schianchi F, Neuweiler A, Wouters T, Gieg H, Dietrich T.   +5 more
europepmc   +1 more source