Results 91 to 100 of about 39,945 (265)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Prominences and magnetic activity on young single and binary stars
, 2008 In this thesis I study the magnetic activity of young stars via observations of stellar prominences on single stars and by applying the Zeeman Doppler imaging (ZDI) technique to map the magnetic fields and measure differential rotation of a young binary ...
Dunstone, Nicholas J.
core +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Direct observation of magnetic cycles in Sun-like stars
, 2011 A sample of 19 solar-type stars, probing masses between 0.6 and 1.4 solar masses and rotation periods between 3.4 and 43 days, was regularly observed using the NARVAL spectropolarimeter at Telescope Bernard Lyot (Pic du Midi, France) between 2007 and ...
Morin, J. +14 more
core +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Laser guide stars and turbulence profiling for extremely large telescopes [PDF]
, 2006 The next generation of ground based telescopes, the so-called extremely large telescopes, will offer a significant leap in sensitivity and resolution compared to current telescopes. They also present a range of technical challenges.
Butterley, Timothy
core
, 2006 High dynamic range imaging produces images with a much greater range of light and color than conventional imaging. The effect is stunning, as great as the difference between black-and-white and color television.
Reinhard, Erik +3 more
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Mapeamento espectral de discos de acréscimo em variáveis cataclísmicas [PDF]
, 2008 Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas. Programa de Pós-Graduação em Física.Esta tese de doutorado é a continuação da dissertação de mestrado defendida em 2004. Nosso projeto visa analisar, com
Saito, Roberto Kalbusch
core
, 2011 Accurately interpreting the imaging findings in patients with prior musculoskeletal tumors can be difficult. Because most patients have anatomical changes related to surgery in addition to postradiation and postchemotherapy changes, the radiologist must ...
Bancroft, Laura W., Laura Bancroft
core +1 more source