Results 71 to 80 of about 39,945 (265)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Modelling the magnetic activity and filtering radial velocity curves of young Suns : the weak-line T Tauri star LkCa 4

, 2014
SGG acknowledges support from the Science & Technology Facilities Council (STFC) via an Ernest Rutherford Fellowship [ST/J003255/1]. SHPA acknowledges financial support from CNPq, CAPES and Fapemig.We report results of a spectropolarimetric and ...
Delfosse, X., G. Hussain, Hébrard, E., R. Fares, X. Delfosse, Dougados, C., R. Doyon, Gregory, S. G.; id_orcid, Gregory, S. G., Ménard, F., S. H. P. Alencar, Hussain, G., C. Dougados, Alencar, S. H. P., Donati, J. -F., Takami, M., I. Boisse, Vidotto, A. A., M. Takami, F. Menard, Grankin, K., Donati, J.F., J. Bouvier, K. Grankin, J. Morin, E. Hebrard, Morin, J., Bouvier, J., Herczeg, G., C. Moutou, Hébrard, Elodie, Fares, R., Jardine, M. M., Hussain, G. A. J., Boisse, I., Moutou, C., Cameron, A. C., Morin, Julien, A. A. Vidotto, Donati, J.-F., G. Herczeg, M. M. Jardine, J.- F. Donati, A. C. Cameron, Doyon, R., Collaboration, The Matysse, S. G. Gregory, Hébrard, Eric   +47 more
core   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

VLT/PIONIER imaging of red supergiant stars

, 2018
PIONIER (Precision Integrated-Optics Near-infrared Imaging ExpeRiment) was the first 4-telescope instrument installed at the Very Large Telescope Interferometer (VLTI) in 2010.
Montargès, Miguel (5124386), Montargès, Miguel   +1 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Magnetic fields of Ap stars from full Stokes spectropolarimetric observations

, 2014
Current knowledge about stellar magnetic fields relies almost entirely on observations of circular polarization. Few objects have been observed in all four Stokes parameters.
Kochukhov, Oleg,, Rusomarov, Naum,, Piskunov, Nikolai,   +2 more
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

An efficient 3D stack-of-stars turbo spin echo pulse sequence for simultaneous T2-weighted imaging and T2 mapping

, 2019
Purpose: To design a pulse sequence for efficient 3D T2-weighted imaging and T2 mapping. Methods: A stack-of-stars TSE pulse sequence with variable refocusing flip angles and a flexible pseudo-random view ordering is proposed for simultaneous T2-weighted
Keerthivasan, Mahesh Bharath, Saranathan, Manojkumar, Altbach, Maria I, Maria I. Altbach, Johnson, Kevin, Ali Bilgin, Craig C. Weinkauf, Weinkauf, Craig C, Bilgin, Ali, Fu, Zhiyang, Martin, Diego R, Diego R. Martin, Manojkumar Saranathan, Kevin Johnson, Zhiyang Fu, Mahesh Bharath Keerthivasan   +15 more
core   +1 more source

On Telescopic Star Images [PDF]

Monthly Notices of the Royal Astronomical Society, 1952
E. H. Linfoot, E. Wolf
openaire   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source