Results 101 to 110 of about 51,001 (265)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Photometric parallaxes and subdwarf identification for M-type stars
, 2012 Photometric data on the Kron-Cousins photometric system have been obtained for 118 new late K to middle M-type stars with known distances. These data have been used to obtain absolute red magnitudes, to construct a color-magnitude diagram, and to compute
Thompson, Dayna L.
core
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Investigating the A-Type Stars Using Kepler Data
, 2013 Rotation is a key physical process operating in the A stars. We present a method by which rotation periods might be measured with Fourier transforms of Kepler data, potentially removing the requirement of spectroscopic observations to acquire similar ...
Murphy, Simon J.
core
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Rotational Velocities of Late-Type Stars
, 1997 A calibration based on the results of Gray has been used to determine projected rotational velocities for 133 bright stars with spectral types of F, G, or K, most of which appear in {The Bright Star Catalogue}. The vast majority have {v} sin {i} ≤q 10 km
Fekel, Francis C.
core
Infrared properties of SiO Maser Sources in Late-Type Stars
, 2000 The results of an SiO maser survey for late-type stars selected by the IRTS (Infrared Telescope in Space) are presented. We have detected SiO J=1-0, v=1 and/or v=2 lines in 27 stars out of 59 stars.
Matsuura, M. +25 more
core +1 more source