Results 141 to 150 of about 18,957 (215)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Coriolis darkening in late-type stars

Astronomy & Astrophysics
Pinçon, C., Petitdemange, L., Raynaud, R., Garcia, L. J., Guseva, A., Rieutord, M., Alecian, E.   +6 more
openaire   +2 more sources

Optimal duration of perioperative antibiotics in radical cystectomy and urinary diversion: a systematic review and meta-analysis. [PDF]

Langenbecks Arch Surg
Mohamed T, Bani Irshid BA, Elhashamy H, Deameh MG, Hassab El-Naby A, Ramez M.   +5 more
europepmc   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Subgiants in NGC 188 reveal that rotationally induced mixing creates the main sequence Li-Dip. [PDF]

Nat Commun
Sun Q, Deliyannis CP, Anthony-Twarog BJ, Twarog BA, Xu XT, Steinhauer A, King JR.   +6 more
europepmc   +1 more source

Intercompartmental communication in senescence

FEBS Open Bio, EarlyView.
Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz, Eleanor J. Wind, Jixiang Leng, Myriam Gorospe   +3 more
wiley   +1 more source

Glucose-functionalized gold nanoparticles for effective photothermal therapy in lung cancer. [PDF]

Sci Rep
Menendez JB, Fusco M, Piccioni F, Benitez CA, Rizzo MM, Andreozzi P, Moya SE, Cardinal MF, Malvicini M.   +8 more
europepmc   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Titanium abundances in late-type stars

Astronomy & Astrophysics
Mallinson, J. W. E., Lind, K., Amarsi, A. M., Barklem, P. S., Grumer, J., Belyaev, A. K., Youakim, K.   +6 more
  +4 more sources

A first look at rocky exoplanets with JWST. [PDF]

Proc Natl Acad Sci U S A
Kreidberg L, Stevenson KB.
europepmc   +1 more source