Results 111 to 120 of about 333,308 (336)

Software Development in Startup Companies: The Greenfield Startup Model

IEEE Transactions on Software Engineering, 2016
Software startups are newly created companies with no operating history and oriented towards producing cutting-edge products. However, despite the increasing importance of startups in the economy, few scientific studies attempt to address software engineering issues, especially for early-stage startups.
Giardino, Carmine, Paternoster, Nicoló, Unterkalmsteiner, Michael, Gorschek, Tony, Abrahamsson, Pekka   +4 more
openaire   +4 more sources

Single‐Target Pairing System (StarPair) for Large‐Scale Interrogation of Cell–Cell Interactions

Advanced Science, EarlyView.
This work presents a single‐target pairing system, StarPair, enabling cell–cell interaction studies by target combination in droplets. StarPair offers superior pairing efficiencies over 95% and operation frequencies of 105 pairs per 9.5 h for two‐target pairing, allowing large‐scale interrogation of immune cell‐cancer cell interactions and precise ...
Tianjiao Mao, Lang Nan, Miao Xu, Kehao Zeng, Yuchao Wang, Ziyu Han, Ho Cheung Shum   +6 more
wiley   +1 more source

Successful commercialisation in startup accelerator programmes: How different startup ecosystems matter

Journal of Innovation & Knowledge
This study examined the influence of the Western Australian and Iranian startup ecosystem contexts, including the powers and liabilities that determine startups’ commercialisation outcomes.
Farzaneh Eslamloo, Kerry Brown, Zahra Amrollahi Biyouki   +2 more
doaj   +1 more source

Detecting Indicators for Startup Business Success: Sentiment Analysis Using Text Data Mining

Sustainability, 2019
The main aim of this study is to identify the key factors in User Generated Content (UGC) on the Twitter social network for the creation of successful startups, as well as to identify factors for sustainable startups and business models. New technologies
José Ramón Saura, P. Palos-Sánchez, A. Grilo   +2 more
semanticscholar   +1 more source

Targeting Peptostreptococcus anaerobius with an Iron‐Based Nanozyme Reverses Ferroptosis Resistance and Enhances Antitumor Immunity in Colorectal Cancer

Advanced Science, EarlyView.
An iron‐based nanozyme selectively eliminates intratumoral P. anaerobius while catalytically generating ROS to induce ferroptosis, synergistically suppressing colorectal cancer growth and activating anti‐tumor immunity through immunogenic cell death. ABSTRACT The intratumoral microbiota is a critical determinant of therapeutic outcomes in colorectal ...
Yinghao Cao, Jun Wang, Hanwenchen Wang, Xiang Sun, Fang Fang, Shiying Li, Jianping Liu, Changrong Shi, Pengyuan Qi, Jianhua Zou, Xiaoyuan Chen, Kailin Cai   +11 more
wiley   +1 more source

USP35 Acts as a Deubiquitinating Enzyme for ID3 to Promote Immune Escape in Colorectal Cancer

Advanced Science, EarlyView.
USP35 stabilizes ID3 expression by deubiquitinating the K2/K30 site, thereby upregulating PD‐L1 and promoting immune escape in colorectal cancer. IU1, an inhibitor of USP35 enzyme activity, has been shown to inhibit USP35, thereby accelerating ID3 degradation, enhancing CD8+ T cell killing, and reversing the immunosuppressive microenvironment ...
Wenxin Chen, Ling Wang, Hongmei Fan, Lisheng Li, Lingyu Zhang, Ruoxin Li, Fang Liu, Fuli Wen, Yunbin Ye, Chuanzhong Huang   +9 more
wiley   +1 more source

V2I-based startup assistance system at signalized intersections

Advances in Mechanical Engineering, 2015
Traffic delays are caused by unskilled vehicle operation and driver distraction during the startup process at signalized intersections. To address this issue, we propose a V2I-based driver assistance system that can acquire the current traffic signal ...
Jianqiang Wang, Yougang Bian, Biao Xu, Hongmao Qin, Manjiang Hu, Bin Huang   +5 more
doaj   +1 more source

Decision Taking for Selling Thread Startup

, 2012
Decision Taking is discussed in the context of the role it may play for a selling agent in a search market, in particular for agents involved in the sale of valuable and relatively unique items, such as a dwelling, a second hand car, or a second hand ...
Bergstra, Jan A.
core  

Genome‐Wide CRISPR Screen Reveals PIK3CA Inhibition Enhances Lipid Nanoparticle‐Mediated siRNA Delivery

Advanced Science, EarlyView.
A genome‐wide CRISPR screen and identifies PIK3CA as a key regulator of lipid nanoparticle (LNP) uptake is performed. Modulating PIK3CA with small‐molecule inhibitor BAY1082439 enhanced LNP uptake, siRNA delivery, and gene silencing in a variety of epithelial cells, and improved therapeutic outcomes in vivo.
Wenhan Wang, Kangfu Chen, Zongjie Wang
wiley   +1 more source

An Elastocaloric Polymer with Ultra‐High Solid‐State Cooling via Defect Engineering

Advanced Science, EarlyView.
This work reports a defect‐engineering strategy that enables a record‐high adiabatic temperature change of up to 8.14 ± 1.76 °C in elastomers at an elevated temperature above 65 °C. Combined experimental and theoretical efforts reveal that increasing dangling‐chain defects nonmonotonically impacts the elastocaloric cooling performance of polymers due ...
Zhaohan Yu, Duo Xu, Zumrat Usmanova, Chuwei Ye, Aditya Swarnkar, Emma Scott, Sizhe Huang, Siyuan Rao, Xinyue Liu, Svetlana V. Boriskina, Ruobing Bai, Shaoting Lin   +11 more
wiley   +1 more source