A brain-specific microRNA, <i>miR-1000</i>, regulates lipid homeostasis via neuropeptide-like precursor 1 in <i>Drosophila melanogaster</i>. [PDF]
Genes DevVerma P +3 more
europepmc +1 more source
Toward Standardization in CO2 Electrolysis: A Round Robin Study
Advanced Energy Materials, EarlyView.CO2 electrolysis is a promising green technology for producing fuels and chemicals. To support its real‐world adoption, researchers conducted a collaborative study to identify sources of experimental variability. They found key differences in temperature and pressure control across labs and proposed a standardized testing protocol to improve ...
Dorottya Hursán +12 more
wiley +1 more source
Global loss of metabolic responsiveness and elevated enzyme in leptin deficient obese mice during starvation. [PDF]
NPJ Syst Biol ApplLi D +16 more
europepmc +1 more source
Uncertainty‐Guided Selective Adaptation Enables Cross‐Platform Predictive Fluorescence Microscopy
Advanced Intelligent Discovery, EarlyView.Deep learning models often fail when transferred to new microscopes. A novel framework overcomes this by selectively adapting the early layers governing low‐level image statistics, while freezing deep layers that encode morphology. This uncertainty‐guided approach enables robust, label‐free virtual staining across diverse systems, democratizing ...
Kai‐Wen K. Yang +9 more
wiley +1 more source
Transcriptome- and phenotype-based epistasis analysis in Caenorhabditis elegans reveals daf-16/FoxO-dependent and independent effects of daf-2/InsR in L1 starvation and recovery. [PDF]
G3 (Bethesda)Fisher K, Chitrakar R, Baugh LR.
europepmc +1 more source
Advanced Intelligent Systems, EarlyView.A statistical and machine learning‐assisted surface‐enhanced Raman scattering (SERS) framework is developed for label‐free quantification of low‐abundance analytes, including proteins. Combining digital SERS event counting with binomial regression and an artificial neural network (ANN) trained on full spectra, the approach achieves picomolar detection ...
Eni Kume, James Rice
wiley +1 more source
Transdiagnostic Neurobiological and Nutritional Factors in Eating Disorders: Implications for Integrative Treatment Models. [PDF]
NutrientsŁucka I +4 more
europepmc +1 more source
Therapeutic Applications of Stimuli‐Based Release and Engineering of Extracellular Vesicles
Advanced NanoBiomed Research, EarlyView.This review summarizes the effects of endogenous and exogenous stimuli, their effects on the natural release of extracellular vesicles, as well as their uptake and release. It also gives an overview of stimuli‐responsive EVs and their therapeutic applications. Extracellular vesicles (EVs), nano‐ to microsized lipid bilayer membrane‐bound particles, are
Gloria Kemunto, Kristen Dellinger
wiley +1 more source
Functional Analysis of Adipokinetic Hormone and Its Receptor Genes in Regulating Energy Metabolism Under Stress Conditions in <i>Dendroctonus armandi</i>. [PDF]
Int J Mol SciWang L, Tang M, Chen H.
europepmc +1 more source
Advanced NanoBiomed Research, EarlyView.CRISPR/Cas9 has revolutionized the field of gene therapy, but delivery remains an outstanding issue. We propose a nonviral gold‐nanoparticle platform for co‐delivery of CRISPR/Cas9 ribonucleoprotein and long 2.1 kilobase dsDNA transgene constructs. This CRISPR‐AuNP is inexpensive to produce and mediate gene editing and DNA delivery in T cells and CD34+
Rachel A. Cunningham +8 more
wiley +1 more source