Results 161 to 170 of about 192,084 (260)

A microRNA generated via lysosomal processing of ribosomal RNA suppresses proinflammatory responses. [PDF]

Life Sci Alliance
Michael D, Feldmesser E, Rajan KS, Lubelsky Y, Bashan A, Damalas A, Ben Zvi S, Friedberg A, Eitan N, Erez S, Yonath A, Ulitsky I, Oren M.   +12 more
europepmc   +1 more source

Pt‐TiO2 mesoporous nanosystem co‐delivering phlorezin enables synergistic sonodynamic‐chemoimmunotherapy for hepatocellular carcinoma via directly targeting DDX5 and metabolic reprogramming modulation

BMEMat, EarlyView.
Abstract Hepatocellular carcinoma (HCC), ranking as the third leading cause of cancer‐related mortality globally, continues to pose significant therapeutic challenges. Here, we developed an innovative nanosystem, Phl@PT, based on Pt‐TiO2 nanoparticles for the co‐delivery of Phlorezin, presenting a novel approach for HCC treatment through sonodynamic ...
Kairui Liu, Bo Zhang, Yue Wan, Zhiru Yang, Abdusami Abdurahman, Mengxin He, Shengtao Hu, Yi Zhang, Xiaoke Li, Jin Chang, Jun Kang, Liren Liu, Wanghua Liu, Shao Li   +13 more
wiley   +1 more source

Nucleophagy is promoted by two autophagy receptors and inhibited by chromatin-nuclear envelope tethering in fission yeast. [PDF]

Nat Commun
Ma ZH, Pan ZQ, Jiang ZD, Shao GC, Hua Y, Suo F, Zou CX, Jiang YF, Dong MQ, Du LL.   +9 more
europepmc   +1 more source

Tetraspanin‐ESCRT sorting drives miR‐29b packaging into extracellular vesicles to reverse fibrosis in intrauterine adhesions

BMEMat, EarlyView.
MiR‐29b is enriched in extracellular vesicles (EVs) via a tetraspanin transporter‐dependent endocytosis and sorting complex required for the endosomal transport (ESCRT)‐dependent pathway. These EVs target the 3′ untranslated region (3′UTR) of TGFB2, thereby inhibiting the TGF‐β/Smad3 signaling pathway and repairing endometrial damage in intrauterine ...
Lihao Chen, Jianfeng Wu, Shunhan Zhang, Siqi Huang, Yingjun Xie, Hongda Chen, Yinghong Yang, Lan Xiao, Ding Wang, Keke Wu, Xiaofang Sun   +10 more
wiley   +1 more source

Optimal Preservation Method for Long-term Preservation in ddH₂O and Starvation Adaptive Mechanisms of Flavobacterium columnare Revealed by Multi-omic Analysis. [PDF]

Microb Ecol
Gao S, Zhong L, Zhang Y, Zhu R, Shao Y, Li R, Zhu Y, Cai W.   +7 more
europepmc   +1 more source

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

A brain-specific microRNA, <i>miR-1000</i>, regulates lipid homeostasis via neuropeptide-like precursor 1 in <i>Drosophila melanogaster</i>. [PDF]

Genes Dev
Verma P, Gowda P, Danial NN, Van Vactor D.   +3 more
europepmc   +1 more source

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

Global loss of metabolic responsiveness and elevated enzyme in leptin deficient obese mice during starvation. [PDF]

NPJ Syst Biol Appl
Li D, Morita K, Kokaji T, Hatano A, Hirayama A, Soga T, Suzuki Y, Matsumoto M, Tsuchiya T, Ozaki H, Ohno S, Inoue H, Inaba Y, Maehara H, Sugimoto H, Pan Y, Kuroda S.   +16 more
europepmc   +1 more source