Results 171 to 180 of about 197,748 (260)

Intermittent Fasting Reduces Taurine Availability and Promotes Antitumor Immunity Through PERK Attenuation‐Associated Paraptosis‐Like Cell Death in Colorectal Cancer

Advanced Science, EarlyView.
This study identifies reduced taurine availability as a mediator of intermittent fasting in colorectal cancer and shows that taurine interacts with GRP78 to maintain PERK abundance post‐transcriptionally. It further shows that taurine depletion destabilizes PERK, induces immunogenic paraptosis, remodels the tumor microenvironment toward a CD8+ T cell ...
Baohui Song, Sikei Kam, Jingyi Liu, Rui Lv, Xucheng Huo, Zhanghan Chen, Yuelun Dong, Shilun Cai, Bing Li, Ruobing Ren, Yunshi Zhong, Mingyan Cai   +11 more
wiley   +1 more source

ER-mitochondria tether ML1 coordinates peripheral fission and wholesale mitophagy for plant adaptation to carbon starvation. [PDF]

Sci Adv
Shi B, Li B, Wang S, Zhang X, Tang Y, Jiang J, Zhai L, Shao Y, Sun J.   +8 more
europepmc   +1 more source

Metabolic‐Redox Remodeling of Inflammatory Synovium by Mannose‐Modified Selenium Nanoparticles for Osteoarthritis Therapy

Advanced Science, EarlyView.
Elevated GLUT1‐driven glycolysis and disrupted selenoprotein‐dependent redox homeostasis drive osteoarthritic progression. Intra‐articular mannose‐modified selenium nanoparticles (M‐SeNPs) selectively target hypermetabolic synovial cells to reprogram aberrant glycolysis and restore endogenous antioxidant defenses.
Yu‐Qing Zou, Chen‐Hao Xu, Bo‐Wei Li, Leung Chan, Yi‐Di Xu, Han‐Bo Su, Rui Peng, Fang‐Ji Luo, Ya‐Chen Peng, Zhen‐Yan Li, Vincent Kam Wai Wong, Xiao‐Fei Zheng, Xing Ma, Zhen‐Gang Zha, Tianfeng Chen, Huan‐Tian Zhang   +15 more
wiley   +1 more source

Darkness Attenuates the Early Transcriptional Response to Phosphate Deficiency in Soybean Roots. [PDF]

Int J Mol Sci
Shaikh A, Thurber I, Sacramento NRM, Bravo J, Viall L, Maniyar R, Ali MM, Nguyen J, Tran K, Parra G, Magdaleno K, Cruz T, Baltrons K, Cazares R, DeLeon B, Flores N, Sommerhalter M, Uhde-Stone C.   +17 more
europepmc   +1 more source

LigHTS: Biomimetic Hydrogel Photo‐Fabrication for Imaging‐Based Ultra‐High‐Throughput Screening

Advanced Science, EarlyView.
LigHTS removes a key bottleneck for ultra‐high‐throughput screening (UHTS) by enabling biomimetic hydrogel microenvironments to be manufactured directly in standard multiwell plates. A single, collimated UV exposure with formulation‐tuned light penetration patterns an entire plate with UHTS‐grade uniformity (<20% CV), producing structured GelMA films ...
Alessandro Enrico, Sara Rigolli, Julius Zimmermann, Melissa Pezzotti, Eloisa Torchia, Moises Di Sante, Ferdinando Auricchio, Francesco S. Pasqualini   +7 more
wiley   +1 more source

Cobalt starvation affects multiple cellular processes in <i>Desulfofundulus kuznetsovii</i> TPOSR during alcohol oxidation. [PDF]

Microb Genom
Friedeheim L, Boeren S, Sánchez-Andrea I, Stams AJM, Sousa DZ.   +4 more
europepmc   +1 more source

Age‐Related Lamin B1 Deficiency Activates SLC7A11‐Dependent Disulfidptosis to Impair Osteogenesis via Intercepting Mitochondrial Fission

Advanced Science, EarlyView.
This study reveals that age‐related LMNB1 deficiency in mesenchymal stem cells epigenetically upregulates SLC7A11, triggering actin disulfidptosis and mitochondrial dysfunction. This cascade impairs bone formation in senile osteoporosis. Furthermore, researchers identified the FDA‐approved drug naldemedine as a targeted SLC7A11 inhibitor to reverse ...
Wenhui Yu, Qibo Li, Weihao Zhang, Guan Zheng, Junhua Chen, Yipeng Zeng, Zipeng Xiao, Zibin Chen, Ziqian Liu, Yangfeng Lin, Jiajie Lin, Zepeng Su, Zhongyu Xie   +12 more
wiley   +1 more source

Adaptation mechanisms of low-phosphorus stress in plants: physiological responses, molecular regulation, and future perspectives. [PDF]

Front Plant Sci
Zhang J, Pan A, Song Z, Liu X, Zhang J, Zhang G.   +5 more
europepmc   +1 more source

Holistic Top‐to‐Bottom Film Restructuring to Achieve Highly Stable Unencapsulated Perovskite Solar Cells

Advanced Energy Materials, EarlyView.
A novel top‐to‐bottom film restructuring strategy is applied to perovskite films, taking advantage of high penetration of vapor‐phase ligand. A gradient‐distributed 2D perovskite structure is built up from top surface to film bulk, meanwhile, inhomogeneity at the buried interface is mitigated, which leads to high quality perovskite films with improved ...
Zhengyan Jiang, Jiayun Sun, Zhixian Zhang, Peide Zhu, Wenjun Liu, Biao Zhou, Hong Zhang, Baomin Xu, Wallace C. H. Choy   +8 more
wiley   +1 more source

A Low-Dimensional <i>X</i>-<i>ρ</i>-<i>A</i> Allocation Model for Predicting Light-Dependent Biomass, Protein, and Lipid Dynamics in TAP Batch Cultures of <i>Chlamydomonas reinhardtii</i> CC-400. [PDF]

Molecules
Yi L, Du D, Yao B, Lin C, Liu B.
europepmc   +1 more source