Results 41 to 50 of about 507,210 (326)

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

The importance of feeding in the larval development of the ghost shrimp Callichirus major (Decapoda: Callianassidae)

Anais da Academia Brasileira de Ciências, 2008
The present study investigated whether the callianassid Callichirus major shows a lecithotrophic behaviour during larval development. Two experiments were carried out.
Fernando A. Abrunhosa, Danielle C.B. Arruda, Darlan J.B. Simith, Carlos A.M. Palmeira   +3 more
doaj   +1 more source

Starvation Resistance is Associated with Developmentally Specified Changes in Sleep, Feeding and Metabolic Rate

, 2019
Food shortage represents a primary challenge to survival, and animals have adapted diverse developmental, physiological and behavioral strategies to survive when food becomes unavailable.
Brown, Elizabeth B., Gibbs, Allen G., Kayser, Matthew S., Keene, Alex C., Kerbs, Arianna, Slocumb, Melissa E., Szuperak, Milan   +6 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Elevated plasma levels of the appetite-stimulator ACBP/DBI in fasting and obese subjects

Cell Stress, 2021
Eukaryotic cells release the phylogenetically ancient protein acyl coenzyme A binding protein (ACBP, which in humans is encoded by the gene DBI, diazepam binding inhibitor) upon nutrient deprivation. Accordingly, mice that are starved for one to two days
Sijing Li, Adrien Joseph, Isabelle Martins, Guido Kroemer   +3 more
doaj   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Lecithotrophic behaviour in zoea and megalopa larvae of the ghost shrimp Lepidophthalmus siriboia Felder and Rodrigues, 1993 (Decapoda: Callianassidae)

Anais da Academia Brasileira de Ciências, 2008
Food supply is considered critical for a successful culturing of decapod larvae. However, some species may present yolk reserve sufficient to complete their larval development without external food supply (known as lecithotrophic larval development).
Fernando A. Abrunhosa, Darlan J.B. Simith, Carlos A.M. Palmeira, Danielle C.B. Arruda   +3 more
doaj   +1 more source

Functional Characterization of Primordial Protein Repair Enzyme M38 Metallo-Peptidase From Fervidobacterium islandicum AW-1

Frontiers in Molecular Biosciences, 2020
The NA23_RS08100 gene of Fervidobacterium islandicum AW-1 encodes a keratin-degrading β-aspartyl peptidase (FiBAP) that is highly expressed under starvation conditions. Herein, we expressed the gene in Escherichia coli, purified the recombinant enzyme to
Jae Won La, Immanuel Dhanasingh, Hyeonha Jang, Sung Haeng Lee, Dong-Woo Lee   +4 more
doaj   +1 more source

Thymine starvation causes abortive initiation of chromosome replication critical for cell death in Escherichia coli [PDF]

, 2013
Presentado en: XXXVI Congreso SEBBM (Sociedad Española de Bioquímica y Biología Molecular), Madrid, 4-6 septiembre, 2013Thymineless death (TLD), a phenomenon in which thymine auxotrophy becomes lethal when cells are starved for thymine, can be prevented
Guzmán Cabañas, Elena, Mata Martín, Carmen, Viguera-Minguez, Enrique   +2 more
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source