Results 41 to 50 of about 191,774 (262)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Upregulation of tryptophanyl-tRNA synthethase adapts human cancer cells to nutritional stress caused by tryptophan degradation

OncoImmunology, 2018
Tryptophan (Trp) metabolism is an important target in immuno-oncology as it represents a powerful immunosuppressive mechanism hijacked by tumors for protection against immune destruction.
Isabell Adam, Dyah L. Dewi, Joram Mooiweer, Ahmed Sadik, Soumya R. Mohapatra, Bianca Berdel, Melanie Keil, Jana K. Sonner, Kathrin Thedieck, Adam J. Rose, Michael Platten, Ines Heiland, Saskia Trump, Christiane A. Opitz   +13 more
doaj   +1 more source

Regulation of the development of flight muscles in long-winged adults of the flightless bug Pyrrhocoris apterus (Heteroptera: Pyrrhocoridae)

European Journal of Entomology, 2008
We studied the development of the indirect flight muscles and reproductive organs in long-winged (macropterous) adults of the flightless bug Pyrrhocoris apterus (L.) and the factors involved in flight muscles histolysis by means of total protein analysis.
Radomír SOCHA, Jan ŠULA
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

The effect of running and starvation interventions on atherogenic index and Xbp1 gene expression in the endoplasmic reticulum of liver in non-alcoholic fatty liver rats [PDF]

Medical Laboratory Journal
Background: Running and starvation can have a positive effect on the reticulophagy of the liver tissue. The purpose of this research was to investigate the effect of running and starvation interventions on the atherogenic index and Xbp1 gene change in ...
Mahshad Paziraee, Habib Asgharpour, Asra Askari, Reza Rezaei Shirazi, Neda Aghaei Bahman Beglo   +4 more
doaj  

Adaptive Physiological and Morphological Adjustments Mediated by Intestinal Stem Cells in Response to Food Availability in Mice

Frontiers in Physiology, 2019
Several studies have evaluated plastic changes in the morphology of the digestive tract in rodents subjected to caloric restriction or restricted availability.
Isaac Peña-Villalobos, Isaac Peña-Villalobos, Ignacio Casanova-Maldonado, Pablo Lois, Pablo Sabat, Pablo Sabat, Verónica Palma   +6 more
doaj   +1 more source

Starvation and refeeding influence the growth, biochemical index, intestinal microbiota, and transcriptomic profiles of golden pompano Trachinotus ovatus (Linnaeus 1758)

Frontiers in Marine Science, 2022
Starvation is a common stress in fish that is caused by environmental changes, and refeeding after starvation is believed to cause compensatory growth.
Bo Liu, Bo Liu, Hua-Yang Guo, Hua-Yang Guo, Hua-Yang Guo, Bao-Suo Liu, Bao-Suo Liu, Bao-Suo Liu, Bao-Suo Liu, Nan Zhang, Nan Zhang, Nan Zhang, Jing-Wen Yang, Liang Guo, Liang Guo, Liang Guo, Shi-Gui Jiang, Shi-Gui Jiang, Shi-Gui Jiang, Dian-Chang Zhang, Dian-Chang Zhang, Dian-Chang Zhang, Dian-Chang Zhang, Dian-Chang Zhang   +23 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

“From spoiling natives to no work, no food”: Food scarcity and the controversy of food rations during the South African War

Scientia Militaria, 2022
Food became scarce during the South African War (1899–1902), which led to large numbers of the population dying from starvation or diseases related to hunger. This was due to certain towns in the country being under siege, while farms and homesteads were
Mpho Manaka
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source