Results 171 to 180 of about 1,741,412 (341)

STUDIUL POLIZAHARIDELOR PRODUSE DE CIANOBACTERIA SPIRULINA PLATENSIS LA CULTIVARE MIXOTROFĂ

Studia Universitatis Moldaviae: Stiinte reale si ale naturii, 2019
În prezentul studiu a fost evaluat efectul  acetaţilor de Cu(II) şi Zn(II) cu şi fără adaos de glucoză şi al iluminării asupra productivităţii şi producerii polizaharidelor intracelulare la cianobacteria Spirulina platensis.
Valentina BULIMAGA, Liliana ZOSIM, Alina TROFIM, Veaceslav REVA, Maria-Bianca BULIMAGA   +4 more
doaj  

Spatially Resolved Multiomics Reveals Metabolic Remodeling and Autophagy Activation in Adamantinomatous Craniopharyngiomas

Advanced Science, EarlyView.
Multiomics integration analysis reveals the “cystic fluid–tumor cell” metabolic coupling that mediates active choline/ethanolamine uptake of tumor cells from cystic fluid and PC/PE synthesis pathways reprogramming that mediating autophagy pathway activation within ACP. ABSTRACT Adamantinomatous craniopharyngioma (ACP), a benign yet highly recurrent and
Dongting Chen, Yahui Gao, Yulin Wang, Ting Lei, Zheng Qu, Yuhan An, Jiaxu Fu, Xin Li, Fangjun Liu, Yan Li   +9 more
wiley   +1 more source

Conversion of Transplanted Mature Hepatocytes into Afp+ Reprogrammed Cells for Liver Regeneration After Injury

Advanced Science, EarlyView.
Donor‐derived tdTomato+ mature hepatocytes were FACS‐isolated and transplanted into Fah−/− host mice. During regeneration, these cells convert into proliferative, unipotent Afp+ rHeps. Their plasticity is governed by a PPARγ/AFP‐dependent metabolic switch, segregating into pro‐proliferative Afplow and pro‐survival Afphigh subpopulations.
Ting Fang, Chao Yang, Hua Qiu, Yuan Du, Xicheng Wang, Yuting Li, Mingyang Xu, Changcheng Liu, Xiuhua Li, Na Guo, Jun Shi, Wencheng Zhang, Zhiying He   +12 more
wiley   +1 more source

UTILIZAREA UNOR ALGE CIANOFITE FIXATOARE DE AZOT ÎN CALITATE DE BIOFERTILIZANŢI LA CULTIVAREA TOMATELOR ÎN CONDIŢII DE SERĂ

Studia Universitatis Moldaviae: Stiinte reale si ale naturii, 2017
Datorită proprietăţii de fixare biologică a azotului atmosferic şi altor caracteristici fiziologice, algele cianofite au un potenţial important de stimulare a productivităţii plantelor de cultură, având premise majore de aplicare intensă în agri­cultura ...
Sergiu DOBROJAN, Victor ŞALARU, Irina STRATULAT, Galina DOBROJAN, Evghenii SEMENIUC   +4 more
doaj  

The potential and controversy of targeting STAT family members in cancer.

Seminars in Cancer Biology, 2020
Yannick Verhoeven, Sam Tilborghs, J. Jacobs, J. De Waele, Delphine Quatannens, C. Deben, H. Prenen, P. Pauwels, X. Trinh, Wouters An, E. Smits, F. Lardon, Peter A. van Dam   +12 more
semanticscholar   +1 more source

Depletion of the RNA‐Editing Enzyme ADAR1 Invigorates the Antitumor Immunity of NK Cells

Advanced Science, EarlyView.
ADAR1 is upregulated in NK cells from melanoma patients, impairing their function. Its loss enhances NK cell tumor infiltration and cytotoxicity in vitro and in vivo. Mechanistically, ADAR1 deficiency destabilizes CD38 mRNA to reduce its expression, thereby increasing NK cell mobility and killing, which nominates it as a therapeutic target for NK cell ...
Shuhan Chen, Di Lu, Rukang Liang, Weikeng Tan, Erming Zhao, Sihuang Wu, Xintong Li, Yulong Song, Miaojian Wan, Xiaoyuan Xie, Qi Zhang, Qiuli Liu   +11 more
wiley   +1 more source

SINTEZA UNOR TIOSEMICARBAZONE ÎN BAZA N-{4-[(HIDRAZINILCARBONOTIOIL)AMINO]FENIL}ACETAMIDEI

Studia Universitatis Moldaviae: Stiinte reale si ale naturii, 2017
În articol sunt descrise metodele de sinteză a șase compuși organici, dintre care trei nu sunt cunoscuți în literatura de specialitate. Structura compușilor a fost determinată cu ajutorul spectroscopiei: RMN 1H,13C și IR.
Roman RUSNAC, Anna RUSNAC, Olga GARBUZ, Nicanor BARBĂ, Aurelian GULEA   +4 more
doaj  

TOPK Inhibition Promotes Anti‐Tumor Immunity Via eIF4F Complex Mediated STAT1 Translation in Gastric Cancer

Advanced Science, EarlyView.
This study identifies TOPK as a dual‐function target in gastric cancer: it drives tumor cell proliferation and migration, and under IFN‐γ stimulation, phosphorylates eIF4F complex component eIF4A1 to enhance STAT1 mRNA translation, thereby promoting PD‐L1/IDO1‐mediated tumor immunometabolic evasion.
Junbing Chen, Longtao Huangfu, Gangjian Wang, Xueying Wang, Huanbo Zhu, Qian Yao, Cong Chen, Xiaohuan Tang, Ting Guo, Biao Fan, Xingyang Liu, Qingda Li, Zining Liu, Ying Hu, Tianze Sun, Jiafu Ji, Xiaofang Xing   +16 more
wiley   +1 more source

SINTEZA ȘI STUDIUL PROPRIETĂȚILOR ANTIOXIDATIVE ALE UNOR NOI DERIVAȚI AI BENZOXAZOLILOR

Studia Universitatis Moldaviae: Stiinte reale si ale naturii, 2018
În lucrare este descrisă sinteza a 4 derivați noi ai benzoxazolilor care manifestă proprietăți biologice. A fost stabilită structura compușilor sintetizați cu ajutorul spectroscopiei 1H,13C-RMN, IR, iar pentru N-[2-(dimetilamino)-1,3-benzo­xazol-5-il]-2-[
Anna RUSNAC, Roman RUSNAC, Olga GARBUZ, Nicanor BARBĂ, Aurelian GULEA   +4 more
doaj  

Discovery of an Adaptive Neuroimmune Response Driving Itch and Fast Tick Removal with Implications for Preventing Pathogen Transmission

Advanced Science, EarlyView.
Doehl et al. discovered an adaptive neuroimmune mechanism that induces itch in tick‐exposed guinea pigs, enabling rapid tick removal. This itch‐induced tick removal (IITR) is mediated by an adaptive cellular immune response and is independent of IgG, IgE, or TRPV1.
Johannes S. P. Doehl, Tiago D. Serafim, Serena Doh, Charles S. Grugan, Eva Iniguez, Luana Rogerio, Ronja Frigard, Ranadhir Dey, Pedro Cecilio, Xinglong Gu, Pang‐Yen Tseng, Aline da Silva Moreira, Mahnaz Minai, James Oristian, Hans Ackerman, Steven Brooks, Caroline Percopo, Siu‐Ping Ng, Derron A. Alves, Lucas Tirloni, Jennifer M. Anderson, Adriana Marques, Fabiano Oliveira, Shaden Kamhawi, Daniel E. Sonenshine, José M. C. Ribeiro, Mark Hoon, Jesus G. Valenzuela   +27 more
wiley   +1 more source