Results 41 to 50 of about 1,741,412 (341)

Alterations in mRNA expression of STAT1, STAT2, STAT3 and STAT5 genes and a potential role of methylation in regulation of their expression in psoriatic arthritis

open access: yesPediatria i Medycyna Rodzinna, 2019
Aim: The goals of this study were to analyse STAT1, STAT2, STAT3 and STAT5 gene expression profiles in psoriatic arthritis patients in comparison to healthy volunteers (control group) and to determine a potential role of methylation in the regulation of ...
Beniamin Grabarek   +2 more
doaj   +1 more source

An Interview With Albert W. Tucker [PDF]

open access: yes, 1983
The mathematical career of Albert W. Tucker, Professor Emeritus at Princeton University, spans more than 50 years. Best known today for his work in mathematical programming and the theory of games (e.g., the Kuhn-Tucker theorem, Tucker tableaux, and the ...
Maurer, Stephen B., Tucker, A. W.
core   +2 more sources

Characterization of Selective and Potent JAK1 Inhibitors Intended for the Inhaled Treatment of Asthma

open access: yesDrug Design, Development and Therapy, 2022
Magnus Nilsson,1 Magdalena Rhedin,2 Ramon Hendrickx,3 Susanne Berglund,1 Antonio Piras,2 Parmis Blomgran,2 Anders Cavallin,2 Mia Collins,2 Göran Dahl,4 Bilel Dekkak,5 Therese Ericsson,3 Niklas Hagberg,6 Ann Aurell Holmberg,3 Agnes Leffler,2 Anders J ...
Nilsson M   +26 more
doaj  

Inhibitors of CK2 Kinase for the Treatment of Gliomas and Other Brain Tumors [PDF]

open access: yesActa Poloniae Pharmaceutica
Protein kinase CK2 has become a target of experimental antiglioma therapies as laboratory data are almost uniformly favorable and the number of synthetized CK2 inhibitors is rapidly growing.
Emanuela B. Pucko, Robert P. Ostrowski
doaj   +1 more source

The molecular details of cytokine signaling via the JAK/STAT pathway

open access: yesProtein Science, 2018
More than 50 cytokines signal via the JAK/STAT pathway to orchestrate hematopoiesis, induce inflammation and control the immune response. Cytokines are secreted glycoproteins that act as intercellular messengers, inducing proliferation, differentiation ...
Rhiannon Morris, N. Kershaw, J. Babon
semanticscholar   +1 more source

An aberrant STAT pathway is central to COVID-19

open access: yesCell Death and Differentiation, 2020
COVID-19 is caused by SARS-CoV-2 infection and characterized by diverse clinical symptoms. Type I interferon (IFN-I) production is impaired and severe cases lead to ARDS and widespread coagulopathy.
T. Matsuyama   +4 more
semanticscholar   +1 more source

Caracterizarea comunităților algale ale lacului Rîșcani (or.Chișinău) prin prisma relațiilor interspecifice

open access: yesActa et Commentationes: Ştiinţe Exacte şi ale Naturii, 2021
În cadrul comunităților algale acționează un șir de factori atât biotici, cât și abiotici. Indivizii unei populaţii, prin elaborare de diverse substanţe biologice, acţionează benefic sau dăunător faţă de indivizii altor populaţii de alge.
Boris Nedbaliuc   +6 more
doaj   +1 more source

JAK–STAT Signaling as a Target for Inflammatory and Autoimmune Diseases: Current and Future Prospects

open access: yesDrugs, 2017
The Janus kinase/signal transduction and activator of transcription (JAK–STAT) signaling pathway is implicated in the pathogenesis of inflammatory and autoimmune diseases including rheumatoid arthritis, psoriasis, and inflammatory bowel disease.
Shubhasree Banerjee   +4 more
semanticscholar   +1 more source

STAT proteins: a kaleidoscope of canonical and non-canonical functions in immunity and cancer

open access: yesJournal of Hematology & Oncology, 2021
STAT proteins represent an important family of evolutionarily conserved transcription factors that play key roles in diverse biological processes, notably including blood and immune cell development and function.
N. Awasthi, Clifford Liongue, A. Ward
semanticscholar   +1 more source

Statul – persoană juridică de drept public [PDF]

open access: yesRevista Institutului Naţional de Justiţie
Statul, ca persoană juridică de drept public, este subiectul central al raporturilor juridice ce vizează organizarea și funcţionarea puterii în societate.
Preţivatîi Ghenadie
doaj   +1 more source

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