Results 91 to 100 of about 34,520,301 (258)

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

State Space Correspondence and Cross-Entropy Methods in the Assessment of Bidirectional Cardiorespiratory Coupling in Heart Failure

Entropy
The complex interplay between the cardiac and the respiratory systems, termed cardiorespiratory coupling (CRC), is a bidirectional phenomenon that can be affected by pathologies such as heart failure (HF).
Beatrice Cairo, Riccardo Pernice, Nikola N. Radovanović, Luca Faes, Alberto Porta, Mirjana M. Platiša   +5 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

A rare tropical storm event drives partial nursery evacuation by juvenile white sharks, followed by rapid aggregation reformation

Movement Ecology
Extreme weather events, such as tropical storms, can pose profound disruption to nearshore marine environments. Although coastal ecosystems are particularly vulnerable to storm impacts, research describing the response of marine taxa to extreme weather ...
Jack T. Elstner, Emily Spurgeon, Patrick Rex, Elizabeth Jahn, Zachariah Merson, Whitney Jones, Lauren Faulkner, James Anderson, Ryan Logan, Wave Moretto, Theodora Mautz, Rilee Sanders, Max Titcomb, Gabriel Gekas, Christopher G. Lowe, Brice X. Semmens   +15 more
doaj   +1 more source

Efficient Methods for Modeling Correlations Among Renewable Energy Sources in State-Space Sampling Monte Carlo Simulation

Energies
This paper compares two combined methods for modeling correlations among multiple random variables in the state-space sampling approach that is adopted in non-sequential Monte Carlo Simulation.
Carmen L. T. Borges, Mateus O. Vaz, Andressa S. Santos, Gonçalo Fontenele, Roberta C. Souza, Claudio E. Carvalho, Angela Russo   +6 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

SUBSPACE IDENTIFICATION METHOD FOR STOCHASTIC LINEAR CONTROL SYSTEMS

Ural Mathematical Journal
Subspace identification is studied for stochastic linear control systems in state-space form. PO-MOESP (Past Outputs Multivariable Output-Error State sPace) algorithm is described, implemented and compared with other subspace identification methods and ...
Nikita M. Kharkovskii, Nikolai B. Melnikov   +1 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source