Results 81 to 90 of about 2,190,945 (258)
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Inference for Adaptive Time Series Models: Stochastic Volatility and Conditionally Gaussian State Space Form [PDF]
In this paper we replace the Gaussian errors in the standard Gaussian, linear state space model with stochastic volatility processes. This is called a GSSF-SV model.
Neil Shephard, Charles S. Bos
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Subspace system identification
Iranian Journal of Electrical and Electronic Engineering, 2005 We give a general overview of the state-of-the-art in subspace system identification methods. We have restricted ourselves to the most important ideas and developments since the methods appeared in the late eighties.
J. Poshtan, H. Mojallali
doaj
Linear Offset-Free Model Predictive Control in the Dynamic PLS Framework
Information, 2018 This work addresses the model predictive control (MPC) of the offset-free tracking problem in the dynamic partial least square (DyPLS) framework. Firstly, state space MPC based on the DyPLS is proposed.
Ligang Hou, Ze Wu, Xin Jin, Yue Wang
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Parameterisation and Efficient MCMC Estimation of Non-Gaussian State Space Models [PDF]
The impact of parameterisation on the simulation efficiency of Bayesian Markov chain Monte Carlo (MCMC) algorithms for two non-Gaussian state space models is examined.
Chris M Strickland +2 more
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State space analysis of diphtheria pathogenesis using semi-tensor products and permutation methods [PDF]
Network BiologyIn this study, we analyze the state space of a Boolean network modeling diphtheria pathogenesis, focusing on key genes such as Tox, Rep, INF1/INF2, TLR, AP1, IL6, and TNF.
Ugbene Ifeanyichukwu Jeff +1 more
doaj
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Automatic forecasting with a modified exponential smoothing state space framework [PDF]
A new automatic forecasting procedure is proposed based on a recent exponential smoothing framework which incorporates a Box-Cox transformation and ARMA residual corrections.
Alysha M De Livera
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