Results 131 to 140 of about 3,133,345 (310)
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
A Latent Variable Approach for the Construction of Continuous Health Indicators [PDF]
In most health survey the state of health of individuals is measured through several different kinds of variables such as qualitative, discrete quantitative or dichotomic ones.
David Conne, Maria-Pia Victoria-Feser
core
Health-related quality of life and well-being health state values among Dutch oldest old
Patient Preference and Adherence, 2019 Riaan Botes,1 Karin M Vermeulen,1 Anthonie M Gerber,2 Adelita V Ranchor,3 Erik Buskens11Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, 9700 RB, The Netherlands; 2Department of Basic Medical Sciences ...
Botes R +4 more
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FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Aviation noise overload in the immediate proximity of the Warsaw-Okecie airport [PDF]
The results are presented for investigations on noise overload around the Warszawa-Okecie airport on persons inhabiting the area where it exceeds 100 dB for a single aircraft flight. Of 256 subjects, 91.1 percent complained about aircraft noise overload.
Koszarny, Z., Maziarka, S.
core +1 more source
In the shadow of exclusion: the state of New Zealand Asian health
New Zealand Medical Student Journal, 2019 New Zealand (NZ) Asians have a long history in Aotearoa dating back to the 19th century, with especially pronounced increases in migration over the past few decades. This ethnic category is an exceptionally broad term, which incorporates individuals with
Rex Liao
doaj
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
State of health economic evaluation research in Saudi Arabia: a review
ClinicoEconomics and Outcomes Research, 2012 Sinaa A Al-AqeelClinical Pharmacy Department, King Saud University, Riyadh, Saudi ArabiaBackground: If evaluation of economic evidence is to be used increasingly in Saudi Arabia, a review of the published literature would be useful to inform policy ...
Al-Aqeel SA
doaj