Results 61 to 70 of about 2,190,995 (307)

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

FEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez, Mikael Oliveberg, Peter Brzezinski   +2 more
wiley   +1 more source

Bootstrap prediction intervals in state-space models [PDF]

, 2008
Prediction intervals in state-space models can be obtained by assuming Gaussian innovations and using the prediction equations of the Kalman filter, with the true parameters substituted by consistent estimates. This approach has two limitations.
Ruiz Ortega, Esther, Ro Rodriguez, Esther Ruiz, Rodríguez, Alejandro, Ruiz, Esther, Alejandro Rodriguez   +5 more
core   +1 more source

Electromagnetic transient modelling and simulation of power converters based on a piecewise generalised state–space averaging method

The Journal of Engineering, 2019
Common averaging methods are studied for modelling a grid-connected converter in renewable energy domain to balance accuracy and efficiency of electromagnetic transient simulation. A piecewise generalised state–space averaging (P-GSSA) method is proposed
Lei Wang, Xinchang Deng, Junxian Hou, Tiezhu Wang   +3 more
doaj   +1 more source

Unified AC/DC hybrid admittance modelling and oscillation stability analysis for interlinking voltage source converter system

IET Renewable Power Generation, 2023
The voltage source converter (VSC) interlinking AC and DC power networks is a core equipment in AC/DC hybrid power systems. To analyze the stability of this system based on the impedance method, it is necessary to establish the hybrid AC/DC admittance ...
Hua Xie, Yigang Zhao, Xiangyu Wu, Runni Yu, Yin Xu, Suwei Zhai   +5 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

A self-organizing state-space-model approach for parameter estimation in Hodgkin-Huxley-type models of single neurons [PDF]

, 2012
Traditional approaches to the problem of parameter estimation in biophysical models of neurons and neural networks usually adopt a global search algorithm (for example, an evolutionary algorithm), often in combination with a local search method (such as ...
Aston, John A. D., Straub, Volko A., J. A. D. Aston (7605152), Volko A. Straub (180605), Volko A Straub, Dimitrios V Vavoulis, Jianfeng Feng (48703), John A D Aston, Volko A. Straub (7585415), Vavoulis, Dimitrios V., Feng, Jianfeng, Jianfeng Feng, J. Feng (1603219), V. A. Straub (7605149), John A. D. Aston (180611), D. V. Vavoulis (7605146), Dimitrios V. Vavoulis (180603)   +16 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source