Results 81 to 90 of about 17,742 (234)

Total Chemical Synthesis of Interleukin‐15 and Interleukin‐2: Taming Protein Hydrophobicity and Aggregation by a Versatile Solubilizing Strategy

Angewandte Chemie, EarlyView.
A reducible solubilizing tag strategy (RST‐2.0) enables the synthesis, purification and ligation of difficult peptides while being readily removable just during folding, which overcomes the common challenges from protein hydrophobicity and aggregation. With this method, we achieved the first total synthesis of native and N‐glycosylated IL‐15 as well as
Jingwen Zeng, Haiyan Zhou, Wang Xia, Hongxiang Wu, Xuechen Li   +4 more
wiley   +2 more sources

Risk‐taking increases under boredom [PDF]

, 2019
We examined if boredom is associated with risk‐taking. Although this association has frequently been postulated, it has rarely been tested, and the evidence has thus far been rather indirect and speculative.
van Tilburg, Wijnand A. P.; id_orcid, Kılıç, Ayşenur, Eric R. Igou, Van Tilburg, Wijnand AP, Igou, Eric R., Kilic, Aysenur; id_orcid, Igou, Eric R, Wijnand A.P. van Tilburg, Ayşenur Kılıç   +8 more
core   +1 more source

Exploring Quantum Support Vector Regression for Predicting Hydrogen Storage Capacity of Nanoporous Materials

Advanced Intelligent Discovery, EarlyView.
In this study we employed support vector regressor and quantum support vector regressor to predict the hydrogen storage capacity of metal–organic frameworks using structural and physicochemical descriptors. This study presents a comparative analysis of classical support vector regression (SVR) and quantum support vector regression (QSVR) in predicting ...
Chandra Chowdhury
wiley   +1 more source

Pd/C‐Catalyzed Hydrogenation of CF3‐, CF2H‐, and CF2CO2Et‐containing Pyridines: A Robust Method for Highly Functionalized containing Piperidines

Angewandte Chemie, EarlyView.
A robust and efficient method to access diversely functionalized fluorinated piperidines was developed. The approach features the hydrogenation of polysubstituted pyridines bearing CF3, CF2H, and CF2CO2Et substituents using an inexpensive, readily available heterogeneous Pd/C catalyst under air‐ and moisture‐tolerant conditions, offering an appealing ...
Thibaud Charvillat, Patrick Bernardelli, Marc Daumas, Xavier Pannecoucke, Vincent Ferey, Hassan Oulyadi, Muriel Sebban, Tatiana Besset   +7 more
wiley   +2 more sources

Spiritual boredom is associated with over- and underchallenge, lack of value, and reduced motivation

Communications Psychology
The emotion of boredom has attracted considerable research interest. However, boredom experienced in spiritual contexts (i.e., spiritual boredom) has rarely been investigated.
Thomas Goetz, Jonathan Fries, Lisa Stempfer, Lukas Kraiger, Sarah Stoll, Lena Baumgartner, Yannis L. Diamant, Caroline Porics, Bibiana Sonntag, Silke Würglauer, Wijnand A. P. van Tilburg, Reinhard Pekrun   +11 more
doaj   +1 more source

Bored to Stay Bored: State Boredom Increases Social Comparison

This research aimed to examine a theoretical model that state boredom leads to a motivation to seek meaningfulness, which promotes the engagement of social comparison. We conducted five studies to test our hypothesis. Study 1 and Study 2 found that state
Peng Miao
core   +1 more source

Large Language Model in Materials Science: Roles, Challenges, and Strategic Outlook

Advanced Intelligent Discovery, EarlyView.
Large language models (LLMs) are reshaping materials science. Acting as Oracle, Surrogate, Quant, and Arbiter, they now extract knowledge, predict properties, gauge risk, and steer decisions within a traceable loop. Overcoming data heterogeneity, hallucinations, and poor interpretability demands domain‐adapted models, cross‐modal data standards, and ...
Jinglan Zhang, Xinyi Chen, Xu Ye, Yulin Yang, Bin Ai   +4 more
wiley   +1 more source

Supramolecular Modulation of Photoinduced Charge Transfer: Tuning Between Tunneling and Incoherent Hopping

Angewandte Chemie, EarlyView.
Molecular recognition guest binding can comprehensively modulate photoinduced charge‐transfer dynamics in the cyclophane host, including charge separation and recombination, via coherent superexchange and incoherent hopping. Unlike covalent donor–bridge–acceptor systems, this supramolecular approach avoids tedious syntheses and offers precise tuning of
Xueze Zhao, Guangcheng Wu, Chun Tang, Georgia C. Mantel, Bai‐Tong Liu, Yi‐Kang Xing, Han Han, Shuai Fang, Charlotte L. Stern, J. Fraser Stoddart, Michael R. Wasielewski, Ryan M. Young   +11 more
wiley   +2 more sources

A Failure to Launch: Regulatory Modes and Boredom Proneness

Frontiers in Psychology, 2018
Boredom is a ubiquitous human experience characterized as a state of wanting but failing to engage with the world. Individuals prone to the experience of boredom demonstrate lower levels of self-control which may be at the heart of their failures to ...
Jhotisha Mugon, Andriy Struk, James Danckert   +2 more
doaj   +1 more source

Automated Alignment Powered by Computer Vision Streamlines the Two‐Photon Polymerization‐Based Micro 3D Printing of Multiscale and Multimaterial Structures

Advanced Intelligent Discovery, EarlyView.
Two‐photon polymerization enables high‐resolution microfabrication, but performing alignment when printing multiple structures is difficult. Here, we present a fast, robust, and open‐source protocol for automated alignment on Nanoscribe systems. Achieving ≈0.4 μm accuracy in under 5 s, our protocol reduces time and error in multimaterial printing. This
Daniel Maher, Valentina Mendoza Martinez, Marcin Piotr Piekarczyk, Stefan Sützl, Ada‐Ioana Bunea   +4 more
wiley   +1 more source