Results 61 to 70 of about 170,299 (264)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Echo state property and memory capacity of artificial spin ice
Scientific ReportsPhysical reservoir computing by using artificial spin ice (ASI) has been proposed on the basis of both numerical and experimental analyses. ASI is a many-body system consisting of ferromagnets with various interactions.
Tomohiro Taniguchi
doaj +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Assessment of Flood Vulnerability among Smallholder Farmers in Niger State, Nigeria.
Kufa Journal for Agricultural SciencesFlooding significantly impacts livelihoods, poverty, and human populations. This study assessed flood vulnerability among smallholder farmers in Niger State, Nigeria.
Nofiu Babatunde Nofiu +1 more
doaj +1 more source
Journal of Technology Management & Innovation, 2012 The paper analyzes the absorptive capacities of a group of enterprises from the electric-electronics sector in the state of Tamaulipas Mexico. First, the literature on absorptive capabilities is reviewed, adopting an evolutionist approach.
Francisco García Fernández +2 more
doaj +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
A queuing system with distinct devices as the finite state machine
Vestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2012 Queuing systems with distinct channels are considered. Channels may have different capacities (from each other) and distinct queues. The term “dispatch control” is introduced to optimize the system, considering the average time of service and failure ...
Andrey P Kotenko, Maksim B Bukarenko
doaj +3 more sources
Globalization & State Capacity in Africa
Procedia - Social and Behavioral Sciences, 2010 AbstractThe paper examines the impact of globalization on state capacity in Africa. It problematizes globalization as a central determining factor in building the capable state in Africa. Globalization, although it requires typologizing and contextualizing or historicizing, is used to refer to a complex set of interconnected multi-linear, multifaceted ...
openaire +1 more source
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes
FEBS Letters, EarlyView.Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez +2 more
wiley +1 more source