Results 81 to 90 of about 170,299 (264)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
ManuscritoMost philosophers assume (often without argument) that belief is a mental state. Call their view the orthodoxy. In a pair of recent papers, Matthew Boyle has argued that the orthodoxy is mistaken: belief is not a state but (as I like to put it) an act of
NICHOLAS KOZIOLEK
doaj +1 more source
Rambam Maimonides Medical Journal, 2012 A very troubling issue for health care systems today is that of life-sustaining treatment for patients who have permanently lost their cognitive capacities.
Ofra G. Golan, Esther-Less Marchus
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Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
A Newly Developed Method for Computing Reliability Measures in a Water Supply Network
Operations Research and Decisions, 2016 A reliability model of a water supply network has beens examined. Its main features are: a topology that can be decomposed by the so-called state factorization into a (relatively)small number of derivative networks, each having a series-parallel ...
Jacek Malinowski
doaj
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Generative AI‐Making and State‐Making: Sovereign AI Race and the Future of Digital Geopolitics
Politics and GovernanceThis article examines how intensifying global competition for sovereign AI, fueled by the rise of generative AI, is reshaping state capacity and digital geopolitics.
Zhenyu Wang
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Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Frontiers in Human NeuroscienceIntroductionVoxel hierarchy on dynamic brain graphs is produced by k-core percolation on functional dynamic amplitude correlation of resting-state fMRI.MethodsDirected graphs and their afferent/efferent capacities are produced by Markov modeling of the ...
Dong Soo Lee +9 more
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FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source