Results 91 to 100 of about 3,748,422 (364)

Capturing human category representations by sampling in deep feature spaces [PDF]

open access: yes, 2018
Understanding how people represent categories is a core problem in cognitive science. Decades of research have yielded a variety of formal theories of categories, but validating them with naturalistic stimuli is difficult.
Aghi, Krisha   +4 more
core   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

open access: yesFEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez   +17 more
wiley   +1 more source

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

open access: yesFEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao   +7 more
wiley   +1 more source

Computer Science in Transcaucasia and Baltic States: a Comparative Bibliometric Analysis

open access: yesMathematical Problems of Computer Science, 2019
Based on the Web of Science, InCites database, this article will analyze the publication output of the Transcaucasia and Baltic states in computer science research field, their citations, as well as international collaboration in the field of computer science. The obtained results demonstrate that publications on computer science from the Baltic states
Shushanik Sargsyan, Edita Gzoyan
openaire   +3 more sources

Self-Evaluation Applied Mathematics 2003-2008 University of Twente [PDF]

open access: yes, 2009
This report contains the self-study for the research assessment of the Department of Applied Mathematics (AM) of the Faculty of Electrical Engineering, Mathematics and Computer Science (EEMCS) at the University of Twente (UT).
Mouthaan, A.J., Vegt, J.J.W. van der
core   +1 more source

Intron‐oriented HTLV‐1 integration in an adult T‐cell leukemia/lymphoma cell line sustains expression of intact ift81 mRNA

open access: yesFEBS Letters, EarlyView.
In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi   +5 more
wiley   +1 more source

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

open access: yesFEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää   +2 more
wiley   +1 more source

Cyberspace and Cybersecurity: Problems, Perspectives, Technologies

open access: yesЦифрова платформа: інформаційні технології в соціокультурній сфері, 2018
The purpose of the article is to study and consider the general problems of such an important area of information activity of the state, business, education, science as cyber security.
Oleksandr Tkachenko   +1 more
doaj   +1 more source

TRAF2 binds to TIFA via a novel motif and contributes to its autophagic degradation

open access: yesFEBS Letters, EarlyView.
TRAF family members couple receptor signalling complexes to downstream outputs, but how they interact with these complexes is not always clear. Here, we show that during ADP‐heptose signalling, TRAF2 binding to TIFA requires two short sequence motifs in the C‐terminal tail of TIFA, which are distinct from the TRAF6 binding motif.
Tom Snelling   +4 more
wiley   +1 more source

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