Results 51 to 60 of about 391,544 (276)

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Training of future primary school and computer science teachers in the structure of information systems

Науковий вісник Мукачівського державного університету. Серія "Педагогіка та психологія"
The active renewal of teacher education is driven by the contradiction between the need for new specialists and the lack of a clear strategy for modernising the educational process. The purpose of this study was to highlight all aspects of the process of
O. Ihnatenko, V. Tolmachov, A. Ryabko
doaj   +1 more source

Formal Model for Data Dependency Analysis between Controls and Actions of a Graphical User Interface

Advances in Electrical and Computer Engineering, 2012
End-user development is an emerging computer science discipline that provides programming paradigms, techniques, and tools suitable for users not trained in software engineering. One of the techniques that allow ordinary computer users to develop their
SKVORC, D., ZUZAK, I., SRBLJIC, S.
doaj   +1 more source

Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms

FEBS Letters, EarlyView.
Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze, Stéphane Canaan, Alexandre Gouzy, Pierre Santucci   +3 more
wiley   +1 more source

Features of training 3d computer modeling and visualization of future teachers of informatics

Системный анализ и прикладная информатика, 2019
The cognitive, developing, illustrative potential of three-dimensional computer graphics actualizes the training of future teachers in its technologies.
O. G. Rylova
doaj   +1 more source

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

Feasibility and appropriateness of using electronic hierarchical structures in teaching computer science in primary school

RUDN Journal of Informatization in Education
Problem statement. Modern requirements for teaching computer science in primary schools demonstrate the necessity of using innovative educational technologies.
Esen Y. Bidaibekov, Baglan B. Kaldanov
doaj   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Assessment of Students' Comprehension of Binary Concept Using Computer-Science-Unplugged-Method in a Selected Secondary School in Ilorin, Kwara State

Fountain Journal of Natural and Applied Sciences (FUJNAS), 2018
Computer-Science-Unplugged (C-S-Unplugged) is a method of teaching Computer Science in an interesting, engaging and entertaining way through collection of free learning activities without using a computer.
K. M. Nuhu, N. A. Adedokun-Shittu, A.J.K. Shittu   +2 more
doaj   +3 more sources

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source