Results 61 to 70 of about 4,363,521 (251)
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016 BackgroundAlthough several risk factors for acute kidney injury (AKI) have been identified, early detection of AKI in acute decompensated heart failure patients remains a challenge. The aim of this study was to develop and validate a risk score for early
Li Zhi Zhou +6 more
doaj +1 more source
Engineered circular guide RNAs boost CRISPR/Cas12a- and CRISPR/Cas13d-based DNA and RNA editing
Genome Biology, 2023 Background The CRISPR/Cas12a and CRISPR/Cas13d systems are widely used for fundamental research and hold great potential for future clinical applications.
Xin Zhang +17 more
doaj +1 more source
A Critical Review of the US State Department's 2015 Progress Report on Haiti [PDF]
, 2016 This review, published jointly by the Center for Economic and Policy Research and the Haiti Advocacy Working Group, looks at the US State Department's annual reports on US assistance to Haiti mandated under the 2014 Assessing Progress in Haiti Act.
Alan Yarborough +5 more
core
Elasto-plastic response of reversibly crosslinked biopolymer bundles
, 2014 We study the response of F-actin bundles to driving forces through a simple analytical model. We consider two filaments connected by reversibly bound crosslinks and driven by an external force. Two failure modes under load can be defined. \textit{Brittle
Heussinger, Claus +2 more
core +1 more source
Threshold for the Outbreak of Cascading Failures in Degree-degree Uncorrelated Networks [PDF]
, 2015 In complex networks, the failure of one or very few nodes may cause cascading failures. When this dynamical process stops in steady state, the size of the giant component formed by remaining un-failed nodes can be used to measure the severity of ...
Dong, Fang +7 more
core +3 more sources
This Is Not a Myeloproliferative Neoplasm…
Pediatric Blood &Cancer, EarlyView.
Stephanie Juané Kennedy
wiley +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Self-protecting solid state isolated switch [PDF]
, 1974 Solid state switch has following capabilities: (1) Hybrid or IC from compatible with direct mounting on solar array substrate; (2) Continuous signal is not required to hold it in either on or off state; (3) Separate signal lines for on and off control; (
Gooder, S. T., Hoffman, A. C.
core +1 more source