Results 121 to 130 of about 4,959,587 (308)

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

open access: yesFEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li   +8 more
wiley   +1 more source

Reorganizing State Government

open access: yesThe ANNALS of the American Academy of Political and Social Science, 1924
As has been seen, the Department of Finance was also required to prepare a budget of estimated expenditures and receipts, to be submitted to each regular session of the General Assembly. In the exercise of his general supervision over expenditures, the Director of Finance in effect began the preparation of the budget a biennium in advance.
openaire   +2 more sources

Budget Woes Take Toll on Views of State Governments [PDF]

open access: yes, 2009
Examines trends in favorability ratings of federal, state, and local governments compared to April 2008. Highlights shifts in views of the federal government by political affiliation and links between views of state governments and state budget ...

core  

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

open access: yesFEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand   +2 more
wiley   +1 more source

"The Effect of Government Size on the Steady-State Unemployment Rate: A Dynamic Perspective" [PDF]

open access: yes
The relationship between government size and the unemployment rate is investigated using a panel error-correction model that describes both the short-run dynamics and long-run determination of the unemployment rate.
Burton A. Abrams, Siyan Wang
core  

Midwestern Attitudes on Political Reform [PDF]

open access: yes, 2008
Presents findings from a survey in five Midwestern states of the level of trust in state government, issues of concern, attitudes toward corruption, hope in reform efforts, and proposals for better government.

core  

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

open access: yesFEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

US State Government Crisis Standards of Care Guidelines: Implications for Patients With Cancer.

open access: yesJAMA Oncol, 2021
Hantel A   +5 more
europepmc   +1 more source

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