Results 131 to 140 of about 1,051,927 (309)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Status of state agencies' affirmative action plans and programs [PDF]

open access: yes, 1988
This report to the General Assembly by the South Carolina Human Affairs Commission examines the progress state government has made towards achieving the goal of equal employment opportunity through affirmative action programs.
South Carolina State Human Affairs Commission
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Status of state agencies' affirmative action plans and programs [PDF]

open access: yes, 2017
This report to the General Assembly by the South Carolina Human Affairs Commission examines the progress state government has made towards achieving the goal of equal employment opportunity through affirmative action programs.
South Carolina State Human Affairs Commission
core  

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

open access: yesMolecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht   +3 more
wiley   +1 more source

Status of state agencies' affirmative action plans and programs [PDF]

open access: yes, 2016
This report to the General Assembly by the South Carolina Human Affairs Commission examines the progress state government has made towards achieving the goal of equal employment opportunity through affirmative action programs.
South Carolina State Human Affairs Commission
core  

Reshaping the Government of the Modern State

open access: yesRUDN Journal of Political Science, 2010
The reorganization of government of the modern state includes idea-philosophical component, based on rejection of etatist approach to destination and role of the state and its replacement with liberal approach; organizational component, based on ...
Y A Nisnevich
doaj  

US State Government Crisis Standards of Care Guidelines: Implications for Patients With Cancer.

open access: yesJAMA Oncol, 2021
Hantel A   +5 more
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

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