Results 41 to 50 of about 11,105,488 (338)
Revista de Administração Pública, 2013 Organizações públicas vêm adotando modelos de mensuração de desempenho (MMD), a exemplo da iniciativa privada, buscando gerar incentivos à eficiência de equipes de servidores.
Alyne Anteveli Osajima +1 more
doaj
The role of government in implementation of innovations: a case of Lithuania
Business: Theory and Practice, 2007 The paper deals with factors fostering implementation of innovations into Lithuanian economy. Size of enterprises and sectors of economy have been taken into account.
Manuela Tvaronavičienė +1 more
doaj +1 more source
Cities in American Federalism: Evidence on State–Local Government Conflict from a Survey of Mayors
, 2017 Previous scholarship on American federalism has largely focused on the national government's increasingly conflictual relationship with the states. While some studies have explored the rise of mandates at the state level, there has been comparatively ...
K. Einstein, D. Glick
semanticscholar +1 more source
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1
FEBS Letters, EarlyView.MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson +7 more
wiley +1 more source
Indian Journal of Psychiatry, 2017 Substance use disorder (SUD) is a major problem worldwide, including in India, and contributes significantly to morbidity and mortality. The Ministry of Social Justice and Empowerment, Government of India, addresses the prevention and rehabilitation ...
A. Dhawan +4 more
semanticscholar +1 more source
Towards simplified state government: I. Better state government for washington [PDF]
National Municipal Review, 1921 AbstractOhio and Washington have set their house in order by adopting codes greatly improving their administrative organizations. These represent a big advance in popular government.
openaire +3 more sources
FEBS Letters, EarlyView.Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli +10 more
wiley +1 more source
Local government financial autonomy in Nigeria: The State Joint Local Government Account
Commonwealth Journal of Local Governance, 2010 This paper addresses the statutory financial relations and financial autonomy of local government in Nigeria, and the freedom of local government to generate revenue from its assigned sources without external interference.
Jude Okafor
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Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation
FEBS Letters, EarlyView.The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen +2 more
wiley +1 more source