Results 121 to 130 of about 1,282,605 (359)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

ESTUDO RETROSPECTIVO DE AFECÇÕES EM CÃES SENIS ATENDIDOS EM HOSPITAL VETERINÁRIO DO ESTADO DE SÃO PAULO / RETROSPECTIVE STUDY OF DISEASES IN SENIORS DOGS TREATED AT VETERINARY HOSPITAL IN THE STATE OF SÃO PAULO

, 2020
Elisângela Ramalho da Silva, Elaine de Macedo Garcia Bido, Melina Castilho de Souza Balbueno, Franscinne Brait Narita, Cidéli de Paula Coelho   +4 more
openalex   +1 more source

How Does Payer Mix and Technical Inefficiency Affect Hospital Net Revenue? [PDF]

As changes in the US health care system continue to evolve and change, maintaining the financial viability of hospitals is crucial to the system’s operation. Two lines of inquiry have been pursued in describing factors affecting financial viability.
Hervé Leleu, James Moises, Vivian Valdmanis   +2 more
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The Americans with Disabilities Act at 25: Cause for Celebration and Renewed Resolve [PDF]

, 2015
In this report, we review the progress our nation has made since the historic enactment of the Americans with Disabilities Act (ADA) in 1990. We highlight the critical role that P&As have in enforcing the ADA integration mandate, protecting and ...
Elizabeth Priaulx
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Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

The Role of Information in Medical Markets: An Analysis of Publicly Reported Outcomes in Cardiac Surgery [PDF]

During the past two decades, several public and private organizations have initiated programs to report publicly on the quality of medical care provided by specific hospitals and physicians.
David M. Cutler, Mary Beth Landrum, Robert S. Huckman   +2 more
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Iowa Influenza Surveillance Network Final Report 2006-2008 [PDF]

, 2007
The Iowa Influenza Surveillance Network (IISN) tracks the overall activity, age groups impacted, outbreaks, type and strain, and severity of seasonal influenza. In the 2006-2007 season the network had more than 90 reporting sites that included physicians,

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Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Antibiotic use in different hospital administrative categories: an overview of 10 years of a statewide surveillance program in Brazil

Antimicrobial Stewardship & Healthcare Epidemiology
Objective: The present study aimed to describe ICU antibiotic use based on data reported from 2009 to 2018 to the Nosocomial Surveillance System (NSS) of the State Health Department in the State of Sao Paulo, Brazil. Design: Ecological study. Setting:
Filipe Piastrelli, Denise Brandão de Assis, Geraldine Madalosso, Ícaro Boszczowski   +3 more
doaj   +1 more source

A Pre-Katrina Look At the Health Care Delivery System for Low-Income People in New Orleans [PDF]

, 2006
Provides an overview of the public safety net structure, and how health care was delivered to the low-income and uninsured residents of New Orleans before Hurricane Katrina.

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