Results 131 to 140 of about 3,119,332 (305)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

ENTRE MARX E KEYNES: nem restauração capitalista, nem endividamento público-por uma saída anticapitalista

Revista de Políticas Públicas, 2012
This text deals the relationship between the occurrence of the capitalist crisis, the predicament in the reproduction of private property and state intervention as an agent countercyclical deficit and public debt amplification. In other words, we analyze
José Menezes Gomes
doaj  

Cryo-ET comparison of the hierarchical ultrastructure of silkworm, spider, and artificial silk fibers

Nature Communications
Spider and silkworm silks are renowned for their exceptional mechanical properties, which arises from their ultrastructural organization. However, this architecture remains incompletely understood.
Kai Song, Haonan Zhang, Xueli Zhang, Yan Li, Ping Zhu   +4 more
doaj   +1 more source

Portugal's Growth Paradox, 1870-1950 [PDF]

From 1870 to 1913, the Portuguese economy expanded slowly and diverged from the European core. Contrarily, in the interwar period, Portugal achieved higher growth and partially caught-up to the levels of productivity of Western Europe.
Pedro Lains
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

ssG4-seq for global profiling of strand-specific G-quadruplex structures in mammalian genomes

Nature Communications
DNA G-quadruplexes (G4s), formed by guanine-rich sequences in mammalian genomes, are non-canonical structures implicated in gene regulation. However, their strand-specific genomic distribution and mechanistic roles in transcription remain poorly ...
Sheng Li, Ruoyan Wang, Jinyue Zhang, Changchang Cao, Jiangshan Bai, Zhaokui Cai, Rong Ye, Juan Chen, Wanglong Liu, Chen Lu, Ruitian Li, Yuanchao Xue   +11 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Entrepreneurs' Perceptions of the State Implication in the Business Environment Modelling in Romania

Transylvanian Review of Administrative Sciences, 2013
One of the main economic purposes of state administration in every country is to ensure an enabling business environment. The study has two main objectives: first, to reveal and analyze the perceptions of Romanian SMEs – 99.9% of economic companies ...
Ovidiu NICOLESCU, Ciprian NICOLESCU
doaj  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Analyzing the Dynamics of Relative Prices on a Market with Speculative and Non-Speculative Agents Based on the Evolutionary Model [PDF]

The paper deals with an evolutionary model focused on the relation between the behavior of prices and the structure of the population of economic agents.
Dospinescu, Andrei Silviu
core