Results 241 to 250 of about 4,941,318 (319)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Squamous cell carcinoma in an umbilical cyst: a clinical image. [PDF]

Oxf Med Case Reports
Stevens JV, Aliniagerdroudbari E, Woghiren O, Neill D, Kim S, Isaacson A.   +5 more
europepmc   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Patient-Centered Communication Case: Threatened Miscarriage. [PDF]

J Educ Teach Emerg Med
Rohra A, Ortiz D, Berry S, Donovan C, Novotny N, Cohen S, Lei C, Aldalati A, Stapleton S, Fernandez D.   +9 more
europepmc   +1 more source

Der Arzt am Beginn des 21. Jahrhunderts: Zwischen Hippokrates und Staatsmedizin@@@The physician at the beginning of the twenty-first century: between Hippocrates and State medicine: Einbecker-Empfehlungen der Deutschen Gesellschaft für Medizinrecht (DGMR) e.V.@@@Einbecker recommendations of the German Society for Health Care Law

, 2008
Andreas Wienke
openalex   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

The correlation of lupus anticoagulant and anticardiolipin antibodies with hematological parameters and clinical findings in sickle cell disease at steady state phase. [PDF]

Thromb J
Almorish MA, Elkhalifa AME, Ali MM, Hamad IMA, Aburaida OM, Elbadry RM, Kaloda YS, Salih EMM, Al-Sayaghi KM, Albalawi MAH, Aljohani MM, Saha B.   +11 more
europepmc   +1 more source

A JUDICIALIZAÇÃO DO ACESSO AOS MEDICAMENTOS EM SANTA CATARINA: UM DESAFIO PARA A GESTÃO DO SISTEMA DE SAÚDE The judicialization of access to medicines in Santa Catarina State: a challenge for the management of the health system

, 2013
Alexandra Crispim Boing, Neusa Sens Bloemer, Cláudia Rosane Roesler, Simone Fernandes   +3 more
openalex   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source