Results 61 to 70 of about 77,751 (310)

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

State of Charge Estimation for Lithium-Ion Batteries Using Simple Recurrent Units and Unscented Kalman Filter

Frontiers in Energy Research, 2022
Accurate estimation of the state of charge plays a very important role in ensuring the safe and effective operation of battery lithium-ion batteries and is one of the most important state parameters.
Zhaowei Zhang, Zhaowei Zhang, Xinghao Zhang, Xinghao Zhang, Zhiwei He, Zhiwei He, Chunxiang Zhu, Chunxiang Zhu, Wenlong Song, Mingyu Gao, Mingyu Gao, Yining Song   +11 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Comparative study of methods for integrated model identification and state of charge estimation of lithium-ion battery

, 2018
Model-based observers appeal to both research and industry utilization due to the high accuracy and robustness. To further improve the robustness to dynamic work conditions and battery ageing, the online model identification is integrated to the state ...
Wei, Zhongbao,, Tseng, King Jet,, Wei, Zhongbao, Zhao, Jiyun,, Zou, Changfu,, Lim, Tuti Mariana, Zou, Changfu, Zhao, Jiyun, Tseng, King Jet, Lim, Tuti Mariana,   +9 more
core   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

A comprehensive review of battery state of charge estimation techniques

, 2022
A comprehensive review of battery state of charge estimation ...
S Saha (5006636), Enamul Haque (13069056), M Ul Hassan (14154450), Shama Islam (13094109), N Mendis (13310808), A Mahmud (5837783)   +5 more
core  

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Adaptive state of charge estimation for battery packs [PDF]

, 2014
Rechargeable batteries as an energy source in electric vehicles (EVs), hybrid electric vehicles (HEVs) and smart grids are receiving more attention with the worldwide demand for greenhouse reduction.
Sepasi, Saeed
core