Results 51 to 60 of about 169,909,800 (296)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
, 1991 application/pdfA set of 18 documents provided by the Kansas Division of Emergency Management with resources and information on Chemical Spill/Radiation Emergency Notifications and the Emergency Planning and Community Right-to-Know Act.Chemical Planning ...
Kansas. Division of Emergency Management.
core +1 more source
Applied Sciences, 2022 Background: Comprehensive and evidence-based countermeasures against emerging infectious diseases have become increasingly important in recent years.
Tetsuya Yamada, Shoi Shi
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
COVID-19 and United Kingdom’s legal regulation
RUDN Journal of Law, 2022 There has been an unprecedented impact on the all spheres of society from the novel coronavirus (COVID-19). As it has rapidly become a global pandemic, states around the world had to implement appropriate measures for responding to it containment and ...
Elena A. Sorokina
doaj +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Ausnahmepolitik im Anthropozän? Vom Kampf gegen die Natur zur Integration nicht-menschlicher Akteure
Tr@jectoiresThe article seeks an understanding of exceptional politics for the challenges of the Anthropocene. The Anthropocene is the contemporary geological epoch characterized by a profound human impact on the biological, chemical and physical composition of the ...
Hagen Schölzel
doaj +1 more source
Аналітично-порівняльне правознавство, 2023 Education is the key to the sustainable development of mankind [1; 2]. Observance and protection of the human right to education is an important and urgent issue for the world community, which makes maximum efforts in this area [3].
A.R. Karapetian
doaj +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source