Results 61 to 70 of about 1,340,686 (307)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

open access: yesFEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

State Ownership of Archaeological Heritage

open access: yes, 2023
This thesis examines and compares the State’s ownership of archaeological heritage in Switzerland and Turkey, two countries with contrasting political structures and archaeological contexts. The comparative analysis, which is based on both the movable and immovable parts of archaeological heritage, is later used to formulate general recommendations ...
openaire   +3 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Economic Policy Uncertainty and Corporate Risk-taking in Russian Companies: The Role of Corporate Governance

open access: yesКорпоративные финансы
This study investigates the relationship between economic policy uncertainty (EPU) and corporate risk-taking in Russian firms, focusing on the moderating effects of corporate governance mechanisms.
Regina Gataullina, Maria Kokoreva
doaj   +1 more source

Dividend policy and stock price volatility in an emerging market: Does ownership structure matter?

open access: yesCogent Economics & Finance, 2019
This paper examines the impacts of dividend policy and ownership structure on stock price volatility in the Vietnamese market. The study also tests for the moderating effect of foreign/state ownership on the dividend policy–price volatility relation. The
Thi Kieu Hoa Phan, Nam Hoai Tran
doaj   +1 more source

State ownership and firm performance: Empirical evidence from Chinese listed companies

open access: yesChina Journal of Accounting Research, 2013
While the relationship between state ownership and firm performance has been widely researched, the empirical evidence has provided mixed results. This study applies panel data regression techniques to 10,639 firm-year observations of non-financial ...
Mei Yu
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Care for monuments in Central Europe regarding the revitalisation of the countryside

open access: yesAgricultural Economics (AGRICECON), 2003
The cultural landscape and rural areas are considered to be a key component of the European cultural heritage. The European Landscape Convention, which the Czech Republic signed in the autumn of 2002, was also formulated in this sense.
T. Hájek
doaj   +1 more source

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