Results 111 to 120 of about 7,645,590 (291)
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
POLITICAL PARTIES AND THEIR ROLE IN SAFEGUARDING THE SUPREMACY OF THE CONSTITUTION [PDF]
Strategii Manageriale, 2014 Nowadays, the political scene of the world is stirred by political parties. The separate fronts of the Government, on the one side, and Parliament, on the other, are now obsolete notions, while political parties dominate social life, having become ...
Silvia-Elena, OLARU
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Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Deviant State: Domestic and Foreign Practices
RUDN Journal of LawThe task is to explore the optimal, healthy statehood for society and all its social strata. The focus lies on people’s standard of living, the protection of citizens’ rights and freedoms, and the prospects for their development.
Nikolai A. Vlasenko
doaj +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Известия высших учебных заведений. Поволжский регион: Общественные наукиBackground. The relevance of the article is due to the presence of significant shortcomings in the current Federal Law of August 23, 1996 № 127-FZ “On Science and State Scientific and Technical Policy”. At the present stage, it does not meet the needs of
A.Yu. Sokolov
doaj +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
GLOBALIZATION - RISK OR SECURITY FACTOR FOR EUROPE? [PDF]
Annals: Series on Military Sciences, 2019 A review about globalization. Its beginnings and fundaments. Definitions and backgrounds, historic, contemporary and future aspects. Understanding contemporary globalization under its aspects of global trade & finance and also under its cultural and ...
Teodor FRUNZETI +2 more
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