Results 71 to 80 of about 1,845,031 (293)
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
The Influence of Neoliberalism in Europe [PDF]
Ovidius University Annals: Economic Sciences Series, 2019 Two main orientations can be identified in neoliberalism: a liberal-social one - ordoliberalism and another predominantly conservative. The ordoliberalism (and the social market economy) are the expression of a German cultural and political development ...
Ioana Claudia Dobre
doaj
Constitutional foundations of the organization of local self-government in the Russian Federation
Известия высших учебных заведений. Поволжский регион: Общественные науки, 2023 Background. The work is devoted to the study of the constitutional foundations of organizing the local self-government in the Russian Federation. Various approaches to understanding the category of “constitutional foundations” are revealed.
V.V. Grishin
doaj +1 more source
Assessment on power systems non-deterministic state estimation algorithms
, 2023 Publisher Copyright: © 2022 Elsevier B.V.Power systems are operated in a deterministic way. However, the increase in uncertainties (caused by measurement and communication errors or the absence of complete knowledge of the measured quantity) requires ...
Rodriguez-Seco, J. Emilio +2 more
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Democracia directa, poder y contrapoder: Análisis del referendo del 21 de febrero de 2016 en Bolivia
Bolivian Studies Journal, 2017 The referendum has divided waters between those who defend it as an instrument for empowerment of citizenship and those who reject it as a weapon for the concentration of power in the hands of leaders.
Yanina Welp, Alicia Lissidini
doaj +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
ANARCHIST TEACHING M. A. BAKUNIN AND MODERNITY (TO THE 210TH ANNIVERSARY OF THE THINKER’S BIRTH) [PDF]
Legal BulletinThe relevance of the ar ticle is determined by the presence in the modern world of social problems and contradictions, including in the system of international relations, which are in many ways similar to those that existed in the second half of the 19th
IVANNIKOV I.A.
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source