Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
Dorchester Ballot Audit Report - 2014 Primary Election
, 2014 This audit report by the South Carolina State Election Commission for the 2014 Primary Election in Dorchester County provides reports generated by the iVotronic voting machines and Unity election ...
South Carolina State Election Commission
core
Seawater pH Measurement: A Critical Metrological Assessment of Operational Scales and the Unified pH Scale. [PDF]
Sensors (Basel)Quendera R +6 more
europepmc +1 more source
Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma
Molecular Oncology, EarlyView.Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara +10 more
wiley +1 more source
Orangeburg 2016 Statewide Primary Election Audit Report
, 2016 This audit report by the South Carolina State Election Commission for the 2016 Statewide Primary Election in Orangeburg County provides reports generated by the iVotronic voting machines and Unity election ...
South Carolina State Election Commission
core
Scene-Adaptive Line-Aware Visual Measurement Conditioning for Stereo Visual-Inertial Odometry. [PDF]
Sensors (Basel)Liang Y, Hang B, Li W, Yuan Y, Shen F.
europepmc +1 more source
The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection
Molecular Oncology, EarlyView.Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński +12 more
wiley +1 more source
Florence Ballot Audit Report - 2014 Primary Election
, 2014 This audit report by the South Carolina State Election Commission for the 2014 Primary Election in Florence County provides reports generated by the iVotronic voting machines and Unity election ...
South Carolina State Election Commission
core
What the Overpotential Does Not Tell You: Diagnosing Non-Comparability Across Hydrogen and Oxygen Evolution Benchmarking Metrics. [PDF]
MoleculesTaziwa RT, Ike JN.
europepmc +1 more source
Molecular Oncology, EarlyView.Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis +20 more
wiley +1 more source