Results 121 to 130 of about 18,816,110 (295)
Playing the Game of Praise and Blame: On the Justification of our Responsibility Practices [PDF]
Moderate revisionists about moral responsibility, such as Manuel Vargas, attempt to preserve the backward-looking norms that ordinarily guide praise and blame while arguing that these norms are justified because of their effects. However, some doubt that
Cabantangan, Justice
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
The environment as a challenge for governmental responsibility: The case of the European Water Framework Directive [PDF]
The European Water Framework Directive is shaping a new conception of integrative water protection. In this article, the consequences of the Water Framework Directive in respect to national environmental policy will be discussed in referring to the ...
Petersen, Thomas +2 more
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
New electronic state documents list - January 2024
The monthly New South Carolina State Documents publication by the State Library provides a list of state documents published by state agencies that have been cataloged and added to the South Carolina State Documents Depository.
South Carolina State Library
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
New electronic state documents list -February 2024
The monthly New South Carolina State Documents publication by the State Library provides a list of state documents published by state agencies that have been cataloged and added to the South Carolina State Documents Depository.
South Carolina State Library
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2024 Accreditation Statistical Summary
The purpose of this memorandum is to document the compliance of the South Carolina Department of Public Safety's Office of Professional Responsibility with regards to the CALEA Standards for Law Enforcement Agencies Manual. Attached to this memorandum is
South Carolina. Department of Public Safety. Office of Professional Responsibility
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Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source