Results 91 to 100 of about 5,293,191 (260)
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Aeromonas caviae: A rare case of hepatic abscess
GMS Hygiene and Infection ControlAim: The aim of this report is to present, to our knowledge, the first case of Aeromonas (A.) caviae liver abscess. Methods: The following manuscript describes a case of a 75-year-old female patient with past medical history of pancreatic cancer ...
Aristos Aristodimou +4 more
doaj +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Reception and Placement of Refugees in the United States [PDF]
, 2017 [Excerpt] The U.S. Refugee Admissions Program (USRAP), which is managed by the Department of State (DOS), resettles refugees from around the world in the United States. Once a refugee case is approved for U.S.
Bruno, Andorra
core +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Final Performance Report [PDF]
ArkansasThe goal of the project is to get a basic understanding of the condition of physical collections throughout the state while providing free basic preservation training for those responsible for collections.Institute of Museum and Library ...
Arkansas State Parks, the Arkansas History Commission, the Arkansas State Library, and Amigos Library Services
core
Children's Mental Health in Virginia: System Deficiencies and Unknown Outcomes [PDF]
, 2011 Examines the demand for community-based children's mental health care, the availability of various services in the state, and the need for uniform, accurate data collection across state agencies.
core
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source