Results 51 to 60 of about 889,599 (262)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
A Deep State Space Model for Rainfall‐Runoff Simulations
Water Resources ResearchThe classical way of studying the rainfall‐runoff processes in the water cycle relies on conceptual or physically‐based hydrologic models. Deep learning (DL) has recently emerged as an alternative and blossomed in the hydrology community for rainfall ...
Yihan Wang +4 more
doaj +1 more source
How (i)rrational are we? A case of Croatian inflation
Croatian Operational Research Review, 2015 This paper examines the validity of the rational expectations hypothesis (REH) in the case of Croatian consumers and their inflation estimates. The added value of this paper in comparison to previous similar studies lies in the state space methodology ...
Nataša Erjavec +2 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Actuators, 2013 Due to their fast response, high accuracy and non-friction force, piezo-actuators have been widely employed in multiple degree-of-freedom (DOF) stages for various nano-positioning applications.
Yu Cao, Xiongbiao Chen
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Analytic discrete state-space model of LLC resonant converter
e-Prime: Advances in Electrical Engineering, Electronics and EnergyThe LLC resonant converter has widely been used for having high-frequency soft-switching capability which could lead to high power density power electronic solutions, and higher power conversion efficiency at lower costs.
Elias Yousefi Rezaii, Adriano Carvalho
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Second-Order Extended State-Space Model of Switching Converters
CSEE Journal of Power and Energy SystemsThe state space average model of switching converters transforms time varying differential equations into time invariant differential equations by the averaging method in math.
Renji Huang +3 more
doaj +1 more source