Results 111 to 120 of about 19,149,312 (300)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Energy Conservation as a Factor of Regional Development
Управленческое консультирование, 2018 The article deals with legal and normative requirements for energy conservation and increasing of energy efficiency in the sphere of the Russian economy. We notes a number of problems: low rates of major repairs of residential buildings, contradictory in
Vyacheslav Pavlovich Zakharov
doaj
Dohled nad nadacemi a proměňující se vztah státu a nadací
Acta Universitatis Carolinae IuridicaThis article deals with the supervision of public benefit foundations as special-purpose associations with their own autonomy, the concept of state supervision of foundations, and the relationship between foundations and the state based on current Czech ...
Andrea Bartíková
doaj +1 more source
, 2010 Nebenwirkungen, Fehler, Risiken und Schäden zählen in der sehr jungen Disziplin Supervision noch zu den stiefmütterlich behandelten Forschungsthemen. Im Rahmen einer Abschlussarbeit für die Ausbildung zur akademischen Supervisorin der Donau-Universität ...
Kero, Monika Judith
core +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Revista Jurídica Portucalense, 2023 This paper explores the fundamental principles of administrative guarantees related to the protection of the rights of individuals and legal entities during state control and supervision.
Yurii NAZAR +4 more
doaj
State Supervision of Local Finance
Proceedings of the American Political Science Association, 1904 "Reprinted from the Proceedings of the American Political Science Association, Chicago, Dec. 28-30, 1904." ; Mode of access: Internet.
openaire +2 more sources
Central Bank or Single Financial Supervision Authority: The Romanian Case [PDF]
The process of regulation and supervision of the financial system represents a pillar for the financial stability. A recent trend in the institutional framework for financial supervision is the creation of a Single Supervision Authority for the ...
Albulescu, Claudiu Tiberiu
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source