Results 31 to 40 of about 7,137 (227)

Altered dynamic spontaneous neural activity in minimal hepatic encephalopathy

Frontiers in Neurology, 2022
Background and aims:Abnormal regional neural activity has been identified by the analysis of the static amplitude of low-frequency fluctuation (ALFF) in the setting of minimal hepatic encephalopathy (MHE). Brain activity is highly dynamic.
Jie-Ru Guo, Jia-Yan Shi, Qiu-Yi Dong, Yun-Bin Cao, Dan Li, Hua-Jun Chen   +5 more
doaj   +1 more source

Altered Static and Temporal Dynamic Amplitude of Low-Frequency Fluctuations in the Background Network During Working Memory States in Mild Cognitive Impairment

Frontiers in Aging Neuroscience, 2019
Previous studies investigating working memory performance in patients with mild cognitive impairment (MCI) have mainly focused on the neural mechanisms of alterations in activation. To date, very few studies have investigated background network alterations in the working memory state.
Wang, Pengyun, Li, Rui, Liu, Bei, Wang, Cheng, Huang, Zirui, Dai, Rui, Song, Bogeng, Yuan, Xiao, Yu, Jing, Li, Juan   +9 more
openaire   +5 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Functional Connectivity Dynamics Altered of the Resting Brain in Subjective Cognitive Decline

Frontiers in Aging Neuroscience, 2022
BackgroundSubjective cognitive decline (SCD) appears in the preclinical stage of the Alzheimer's disease continuum. In this stage, dynamic features are more sensitive than static features to reflect early subtle changes in functional brain connectivity ...
Yi-Chia Wei, Yi-Chia Wei, Yi-Chia Wei, Yi-Chia Kung, Wen-Yi Huang, Wen-Yi Huang, Wen-Yi Huang, Chemin Lin, Chemin Lin, Chemin Lin, Yao-Liang Chen, Yao-Liang Chen, Chih-Ken Chen, Chih-Ken Chen, Chih-Ken Chen, Yu-Chiau Shyu, Yu-Chiau Shyu, Ching-Po Lin   +17 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Machine learning analysis reveals aberrant dynamic changes in amplitude of low-frequency fluctuations among patients with retinal detachment

Frontiers in Neuroscience, 2023
BackgroundThere is increasing evidence that patients with retinal detachment (RD) have aberrant brain activity. However, neuroimaging investigations remain focused on static changes in brain activity among RD patients.
Yu Ji, Yuan-yuan Wang, Qi Cheng, Wen-wen Fu, Shui-qin Huang, Pei-pei Zhong, Xiao-lin Chen, Ben-liang Shu, Bin Wei, Qin-yi Huang, Xiao-rong Wu   +10 more
doaj   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley   +1 more source

Disturbances of Dynamic Function in Patients With Bipolar Disorder I and Its Relationship With Executive-Function Deficit

Frontiers in Psychiatry, 2020
Abnormity in brain regional function and inter-regional cooperation have been linked with the dysfunction during cognitive and emotional processing in bipolar disorder (BD) patients.
Yan Liang, Yan Liang, Xiaoying Jiang, Xiaoying Jiang, Wenjing Zhu, Wenjing Zhu, Yonghui Shen, Yonghui Shen, Fengfeng Xue, Fengfeng Xue, Yi Li, Yi Li, Zhiyu Chen, Zhiyu Chen   +13 more
doaj   +1 more source

Changes in dynamic and static brain fluctuation distinguish minimal hepatic encephalopathy and cirrhosis patients and predict the severity of liver damage

Frontiers in Neuroscience, 2023
PurposeMinimal hepatic encephalopathy (MHE) is characterized by mild neuropsychological and neurophysiological alterations that are not detectable by routine clinical examination.
Jiang Ji, Jiang Ji, Yi-yang Liu, Guo-Wei Wu, Yan-Long Hu, Chang-Hua Liang, Xiao-dong Wang   +6 more
doaj   +1 more source