Results 101 to 110 of about 23,085,941 (290)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Solution of Fire Protection in Historic Buildings
Civil and Environmental Engineering, 2016 The paper introduces optimization of the functional use of renovated spaces in historic buildings in terms of fire risk. It brings assessment of fire protection in the folk house Habánsky Dvor, situated in the village of Veľké Leváre, whose function was ...
Iringová Agnes, Idunk Róbert
doaj +1 more source
How Can Vernacular Construction Techniques Sustain Earthquakes: The Case of the Bhatar Buildings
Frontiers in Built Environment, 2018 After the 2005 M7.6 Kashmir earthquake (Pakistan), field observations reported that several buildings manufactured with local traditional techniques resisted well to that strong seismic event.
Raffaele Carabbio +3 more
doaj +1 more source
Value and allocation sensitivity in static Python analyses
, 2020 International audienceSound static analyses for large subsets of static programming languages such as C are now widespread. For example the Astrée static analyzer soundly overapproximates the behavior of C programs that do not contain any dynamic code ...
Raphaël Monat +5 more
core +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
STAТIC ANALYSIS OF CROSS STEEL TRUSSES WITH A RECTANGULAR GRID OF COLUMNS
Современная наука и инновации, 2022 The article presents a model for static analysis of cross structures on rectangular plans with different aspect ratios. The data are compared with the results of numerical and experimental research, including natural tests of experimental and industrial ...
Alexander S. Marutyan
doaj
Type-based Static Analysis of Web Documents with Embedded Executable Components
, 2003 Electronic documents have become an important medium for the exchange of information, and nowhere is this more evident than on the World Wide Web. Web-based documents can be dynamic and interactive with the inclusion of executable elements such as ...
Wright, David Richard
core
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source