Results 131 to 140 of about 7,401,358 (355)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Quadruplex digital flight control system assessment [PDF]

Described are the development and validation of a double fail-operational digital flight control system architecture for critical pitch axis functions. Architectural tradeoffs are assessed, system simulator modifications are described, and demonstration ...
Downing, L. E., Mulcare, D. B., Smith, M. K.   +2 more
core   +1 more source

Assessing Static and Dynamic Features for Packing Detection

Packing is a widely used obfuscation technique for malware to bypass detection tools and hinder reverse engineering. Existing research has already covered methods to detect packing, both with static and dynamic analysis. These methods are based on various features: headers, entropy, API calls, section permissions, etc.
Lucca, Serena, Wauters, Dimitri, Bertrand Van Ouytsel, Charles-Henry, Legay, Axel   +3 more
openaire   +2 more sources

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Increasing Use of Risk Assessment at Release in The Continuing Leverage of Paroling Authorities: Findings from a National Survey [PDF]

, 2016
The Parole Release and Revocation Project launched a national survey of paroling authorities across the United States in 2015. Preliminary results from the survey has allowed the Parole Project team to examine changing and current practices regarding how

core  

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Flight service evaluation of composite helicopter components [PDF]

An assessment of composite helicopter structures, exposed to environmental effects, after four years of commercial service is presented. This assessment is supported by test results of helicopter components and test panels which have been exposed to ...
Lowry, D. W., Rich, M. J.
core   +1 more source

The potential of RIVPACS for predicting the effects of environmental change [PDF]

, 2000
RIVPACS has been used successfully for biological assessment of river water quality but its potential in forecasting the effects of environmental change has not been investigated.
Armitage, P.D.
core  

Thévenin equivalent based static contingency assessment

, 2015
The present invention relates to a method for static security assessment of a power system and a real time static security assessment system for assessing a power system, the power system having a plurality of generators, the plurality of generators being represented in the network by a plurality of voltage controlled nodes, wherein the method for ...
Jóhannsson, Hjörtur, Møller, Jakob Glarbo   +1 more
openaire   +1 more source